{"id":"2b2740db-6c71-5bcd-8ed2-58d5996e5ff0","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-meal-trial","predicate":"reduces","statement":"In a 12-person type-2-diabetes crossover trial, adding 1 g stevioside to a meal reduced glucose incremental AUC by 18% versus maize starch, without a significant change in insulin or GLP-1 AUC.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9f678e98-ba16-55c8-a28c-251e87b18a2d","mechanism_event_label":"A small human meal trial found a glycemic effect but did not confirm every proposed hormonal route.","subject":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"object":{"id":"4672b121-0b7e-5547-a276-4758501aad35","slug":"human-stevioside-meal-glucose-auc","display_name":"Human meal glucose incremental AUC with stevioside","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9f678e98-ba16-55c8-a28c-251e87b18a2d","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-meal-trial-event","event_type":"observed_relationship","label":"A small human meal trial found a glycemic effect but did not confirm every proposed hormonal route.","description":"In a 12-person type-2-diabetes crossover trial, adding 1 g stevioside to a meal reduced glucose incremental AUC by 18% versus maize starch, without a significant change in insulin or GLP-1 AUC.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"4672b121-0b7e-5547-a276-4758501aad35","slug":"human-stevioside-meal-glucose-auc","display_name":"Human meal glucose incremental AUC with stevioside","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"8ae7848b-f172-5e09-8acf-5ca914907b0b","slug":"glucose","display_name":"D-glucose","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"d7ab69c0-cd7d-587c-b315-47af56493182","slug":"insulin","display_name":"Insulin","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"4853afc6-9eaa-547f-91d7-c4dd90082351","slug":"glp-1","display_name":"Glucagon-like peptide 1 / GLP-1","entity_type_key":"peptide"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Acute paired crossover; four-hour blood sampling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small study and gram-level dose; not evidence of long-term disease treatment or of equivalence to rebaudioside A.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A small human meal trial found a glycemic effect but did not confirm every proposed hormonal route.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antihyperglycemic effects of stevioside in type 2 diabetic subjects. · 2004 · https://pubmed.ncbi.nlm.nih.gov/14681845/ · DOI 10.1016/j.metabol.2003.07.013","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4bf0fd17-340e-503d-af9f-81645fac8e1e","evidence_kind":"source_excerpt","locator":"Lines 362-368","start_line":362,"end_line":368,"excerpt":"## stevia-meal-trial\nA small human meal trial found a glycemic effect but did not confirm every proposed hormonal route.\nIn a 12-person type-2-diabetes crossover trial, adding 1 g stevioside to a meal reduced glucose incremental AUC by 18% versus maize starch, without a significant change in insulin or GLP-1 AUC.\nModel: Acute paired crossover; four-hour blood sampling.\nLimitations: Small study and gram-level dose; not evidence of long-term disease treatment or of equivalence to rebaudioside A.\nEvidence access: Primary abstract\nAntihyperglycemic effects of stevioside in type 2 diabetic subjects. · 2004 · https://pubmed.ncbi.nlm.nih.gov/14681845/ · DOI 10.1016/j.metabol.2003.07.013","model_system":"Acute paired crossover; four-hour blood sampling.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"295304c9-609c-5b05-a18f-a00ab7b965ed","stable_key":"import-6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7","title":"Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"a36a82c2f8a0a971ea43e9e742db65f45848d13ab77310c0dd6b5cd55e31fc16","revision_id":"ea0355af-a926-511a-a7f2-1750baa95a8d","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}