{"id":"2ad720cc-974c-59d5-bdcc-fe7174b3966f","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:endocrine-igf1","predicate":"increases_in_recorded_experiment","statement":"IGF-I stimulated thymulin production in TEC preparations.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"8a3a14f1-8687-5d71-a2ac-9a48cbb39b5a","mechanism_event_label":"IGF-I stimulated thymulin production in TEC preparations.","subject":{"id":"30ac775f-8dcf-50a2-aba7-48c47ab2b9a5","slug":"igf1","display_name":"Human insulin-like growth factor I / IGF1","entity_type_key":"protein"},"object":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"evidence_count":1,"mechanism_event":{"id":"8a3a14f1-8687-5d71-a2ac-9a48cbb39b5a","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:endocrine-igf1-event","event_type":"experimental_observation","label":"IGF-I stimulated thymulin production in TEC preparations.","description":"| GH and IGF-I | Both stimulated production in TEC preparations. Blocking IGF-I or its receptor inhibited the GH response, supporting a local IGF-mediated component. The associated human endocrine observations do not isolate that mechanism in vivo. [1992 study](https://pubmed.ncbi.nlm.nih.gov/1619008/) |","status":"provisional","compartment":null,"participants":[{"entity":{"id":"30ac775f-8dcf-50a2-aba7-48c47ab2b9a5","slug":"igf1","display_name":"Human insulin-like growth factor I / IGF1","entity_type_key":"protein"},"role":"tested factor","stoichiometry":null,"state_label":"igf1 exposure","sequence_order":0,"notes":""},{"entity":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary bibliographic record and abstract checked; full methods/figures not comprehensively reviewed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"igf1 exposure\", \"comparator\": \"Matched experimental control\", \"endpoint\": \"IGF-I stimulated thymulin production in TEC preparations.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Preparations and species as specified in statement and source; no direct iodine/selenium cofactor requirement inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Interpret only within the recorded preparation, exposure and comparator. The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"IGF-I stimulated thymulin production in TEC preparations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Growth hormone and insulin-like growth factor-I stimulate hormonal function and proliferation of thymic epithelial cells. | 1992 | DOI 10.1210/jcem.75.1.1619008 | PMID 1619008 | https://pubmed.ncbi.nlm.nih.gov/1619008/","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 93-93; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"133817c3-f1e0-597d-966a-37d49605d880","evidence_kind":"source_excerpt","locator":"Lines 93-93","start_line":93,"end_line":93,"excerpt":"| GH and IGF-I | Both stimulated production in TEC preparations. Blocking IGF-I or its receptor inhibited the GH response, supporting a local IGF-mediated component. The associated human endocrine observations do not isolate that mechanism in vivo. [1992 study](https://pubmed.ncbi.nlm.nih.gov/1619008/) |","model_system":"Preparations and species as specified in statement and source; no direct iodine/selenium cofactor requirement inferred.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"e1871d49-9c6b-547b-a1bb-6e2b9270ca89","stable_key":"import-18100170-a014-51c3-adeb-9dab4162b8cc","title":"Thymulin: detailed mechanisms of action (reviewed 3 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"6e8ed0d7a5e23fc822f2ab418e0c4fb2411c01fcaa330039e8d7d93218cacc88","revision_id":"8c0e3449-9bbd-57c0-bb5e-de83f044f2ac","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}