{"id":"2a85e9dc-470d-5df5-8186-69f1093e2bd2","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-lpi-citrulline-absorption","predicate":"retained","statement":"Citrulline plasma increments after oral loads were similar in LPI homozygotes and controls, unlike diamino-acid increments.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"fd254ffc-b782-5078-909b-df8892a19f65","mechanism_event_label":"A different entry route can bypass this particular transport problem.","subject":{"id":"f53c7bfb-3b91-56fe-bebd-28623cfe13a0","slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"},"object":{"id":"8a23c1dd-1eb4-5f52-ba24-64f127b26a0e","slug":"human-citrulline-absorption","display_name":"Human intestinal citrulline absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fd254ffc-b782-5078-909b-df8892a19f65","stable_key":"a9828b14-fbd7-57bf-9e01-0d52d1b42a1f:citrulline-lpi-citrulline-absorption-event","event_type":"biochemical_relationship","label":"A different entry route can bypass this particular transport problem.","description":"Citrulline plasma increments after oral loads were similar in LPI homozygotes and controls, unlike diamino-acid increments.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"impaired_comparison","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c715e48e-42db-5fac-b4a4-c1285a68d085","slug":"ornithine","display_name":"L-Ornithine","entity_type_key":"small_molecule"},"role":"impaired_comparison","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"5fff6664-209e-5c35-b88e-ac15c1c5fbc0","slug":"l-lysine","display_name":"L-Lysine","entity_type_key":"small_molecule"},"role":"affected_diamino_acid","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"f53c7bfb-3b91-56fe-bebd-28623cfe13a0","slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"8a23c1dd-1eb4-5f52-ba24-64f127b26a0e","slug":"human-citrulline-absorption","display_name":"Human intestinal citrulline absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/citrulline-research/6776014.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6db6a42e66322b8ae26335a4f51284ede7691dcbb91e8cf7d7cd6671bd41b87d\", \"start_char\": 0, \"end_char\": 1189, \"text_sha256\": \"6db6a42e66322b8ae26335a4f51284ede7691dcbb91e8cf7d7cd6671bd41b87d\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Oral amino-acid loading comparison","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Separate diamino-acid and citrulline loads","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Inherited transport disorder, not ordinary competition from mixed dietary protein; the study predates gene identification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Citrulline research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"citrulline","display_name":"L-Citrulline","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human LPI patients, heterozygotes and controls","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A different entry route can bypass this particular transport problem.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[citrulline-p6776014] Intestinal absorption in lysinuric protein intolerance: impaired for diamino acids, normal for citrulline. (1980). https://pubmed.ncbi.nlm.nih.gov/6776014/ DOI: 10.1136/gut.21.6.519","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal amino-acid absorption inferred from plasma and urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"51cc33b4-7fdd-5b72-a25e-4b6e0e40325d","evidence_kind":"source_excerpt","locator":"Lines 840-851","start_line":840,"end_line":851,"excerpt":"### citrulline-lpi-citrulline-absorption\nCitrulline plasma increments after oral loads were similar in LPI homozygotes and controls, unlike diamino-acid increments.\nCondition category: machinery_impairment\nnutrient_topic: Citrulline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A different entry route can bypass this particular transport problem.\norganism: Human LPI patients, heterozygotes and controls\ntissue_or_cell_type: Intestinal amino-acid absorption inferred from plasma and urine\nexperimental_model: Oral amino-acid loading comparison\nlimitations: Inherited transport disorder, not ordinary competition from mixed dietary protein; the study predates gene identification.\nexposure: Separate diamino-acid and citrulline loads\nevidence_span: {\"source_cache\": \"artifacts/citrulline-research/6776014.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6db6a42e66322b8ae26335a4f51284ede7691dcbb91e8cf7d7cd6671bd41b87d\", \"start_char\": 0, \"end_char\": 1189, \"text_sha256\": \"6db6a42e66322b8ae26335a4f51284ede7691dcbb91e8cf7d7cd6671bd41b87d\"}\n[citrulline-p6776014] Intestinal absorption in lysinuric protein intolerance: impaired for diamino acids, normal for citrulline. 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