{"id":"2a7d7797-6c0f-519f-a76e-d1dfa83ebbc4","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-cyp3a4","predicate":"decreased_phenotypic_activity","statement":"After 1 g/day resveratrol for four weeks, the healthy-volunteer study found decreased CYP3A4 phenotypic activity using buspirone as the probe.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"2b29ab1b-374f-503c-8b60-ac21a92e8ec3","mechanism_event_label":"A human drug-metabolism interaction was measured with a specific probe.","subject":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"object":{"id":"54e95ff1-4ffa-5e6f-a4cb-b47e5d2a5bda","slug":"cyp3a4","display_name":"Human cytochrome P450 3A4","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"2b29ab1b-374f-503c-8b60-ac21a92e8ec3","stable_key":"52871722-4aa6-5453-a902-3e76356db327:resveratrol-human-cyp3a4-event","event_type":"observed_relationship","label":"A human drug-metabolism interaction was measured with a specific probe.","description":"After 1 g/day resveratrol for four weeks, the healthy-volunteer study found decreased CYP3A4 phenotypic activity using buspirone as the probe.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"53549e32-e6b4-5f09-94e6-62867b015713","slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"54e95ff1-4ffa-5e6f-a4cb-b47e5d2a5bda","slug":"cyp3a4","display_name":"Human cytochrome P450 3A4","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b54ad93a-6232-5ff2-96ee-aafddaafd9a3","slug":"buspirone","display_name":"Buspirone","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"42 initiated; enzyme activities assessed in 40; before/after pharmacological-dose study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Probe indices are not proof of transcriptional induction or a quantified interaction with every substrate; no medication adjustment follows.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Resveratrol collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"resveratrol","display_name":"Resveratrol","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"A human drug-metabolism interaction was measured with a specific probe.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Resveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20716633/ · DOI 10.1158/1940-6207.CAPR-09-0155","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"71d16f2b-2559-5c62-8722-61b6a7f2716b","evidence_kind":"source_excerpt","locator":"Lines 438-444","start_line":438,"end_line":444,"excerpt":"## resveratrol-human-cyp3a4\nA human drug-metabolism interaction was measured with a specific probe.\nAfter 1 g/day resveratrol for four weeks, the healthy-volunteer study found decreased CYP3A4 phenotypic activity using buspirone as the probe.\nModel: 42 initiated; enzyme activities assessed in 40; before/after pharmacological-dose study.\nLimitations: Probe indices are not proof of transcriptional induction or a quantified interaction with every substrate; no medication adjustment follows.\nEvidence access: Primary full text\nResveratrol modulates drug- and carcinogen-metabolizing enzymes in a healthy volunteer study. · 2010 · https://pubmed.ncbi.nlm.nih.gov/20716633/ · DOI 10.1158/1940-6207.CAPR-09-0155","model_system":"42 initiated; enzyme activities assessed in 40; before/after pharmacological-dose study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2844eda9-a122-5357-ae47-cd58227c5994","stable_key":"import-52871722-4aa6-5453-a902-3e76356db327","title":"Resveratrol: metabolites, target selectivity and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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