{"id":"2a397794-1a46-5fe4-915b-4305d5c1080c","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-human-oxidation-null","predicate":"has_unconfirmed_effect_on","statement":"Most oxidative-damage and inflammation marker changes after pure ergothioneine administration were not statistically significant.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"60443d9c-0a08-506a-a929-0543c7cd312f","mechanism_event_label":"Measured uptake did not establish a broad biomarker benefit.","subject":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"object":{"id":"c7d2af0d-ac33-5263-afd2-2f2259a36584","slug":"human-ergo-oxidative-biomarkers","display_name":"Human oxidative-damage/inflammation biomarkers during ergothioneine intake","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"60443d9c-0a08-506a-a929-0543c7cd312f","stable_key":"59b18080-c560-563d-abc5-bac4ee82a27c:ergothioneine-human-oxidation-null-event","event_type":"observed_relationship","label":"Measured uptake did not establish a broad biomarker benefit.","description":"Most oxidative-damage and inflammation marker changes after pure ergothioneine administration were not statistically significant.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"939c92c3-50ea-5a4a-9654-8e3b94448132","slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c7d2af0d-ac33-5263-afd2-2f2259a36584","slug":"human-ergo-oxidative-biomarkers","display_name":"Human oxidative-damage/inflammation biomarkers during ergothioneine intake","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy-volunteer pharmacokinetic study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Some downward trends were reported; trends are not confirmed treatment effects.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Ergothioneine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ergothioneine","display_name":"L-Ergothioneine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Measured uptake did not establish a broad biomarker benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27488221/ · DOI 10.1089/ars.2016.6778","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"bca16e5d-1e1a-5756-9578-17d1569c4f33","evidence_kind":"source_excerpt","locator":"Lines 480-486","start_line":480,"end_line":486,"excerpt":"## ergothioneine-human-oxidation-null\nMeasured uptake did not establish a broad biomarker benefit.\nMost oxidative-damage and inflammation marker changes after pure ergothioneine administration were not statistically significant.\nModel: Healthy-volunteer pharmacokinetic study.\nLimitations: Some downward trends were reported; trends are not confirmed treatment effects.\nEvidence access: Primary abstract\nAdministration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. · 2017 · https://pubmed.ncbi.nlm.nih.gov/27488221/ · DOI 10.1089/ars.2016.6778","model_system":"Healthy-volunteer pharmacokinetic study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2f037d98-f3d0-5dbe-80d8-90b738f130d6","stable_key":"import-59b18080-c560-563d-abc5-bac4ee82a27c","title":"Ergothioneine: transport, redox chemistry and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"b6def8119f03cfabeec2fb55ba924340dc612e1dd42f05404201fa2b7ced5259","revision_id":"f88c38e6-ffb5-5a68-83ca-4610ca2c2df4","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}