{"id":"2a278861-5388-514d-95b8-d04484b360fb","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:scope-shikimic-acid-prunus-patch-2026","predicate":"has_distinct_compound_or_preparation_comparison","statement":"The shikimic-acid-prunus-patch-2026 record is a distinct-compound or preparation comparison; its biological effects are not assigned to isolated shikimic acid.","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"4ec394a7-47da-5a7e-8cfe-0af8194ebb63","mechanism_event_label":"The shikimic-acid-prunus-patch-2026 record is a distinct-compound or preparation comparison; its biological effects are not assigned to isolated shikimic acid.","subject":{"id":"67ad4a8f-1bf6-59e5-90a6-97b7709024d3","slug":"shikimic-acid","display_name":"Shikimic acid","entity_type_key":"small_molecule"},"object":{"id":"efeb7652-8fe6-5ac9-a77f-ec49c8e6bf24","slug":"shikimic-acid-prunus-patch-2026","display_name":"2026 mixed shikimic-acid/Prunus-mume acne patch","entity_type_key":"chemical_species"},"evidence_count":1,"mechanism_event":{"id":"4ec394a7-47da-5a7e-8cfe-0af8194ebb63","stable_key":"31b1baa4-4113-5541-b9e7-fe44a5253a07:scope-shikimic-acid-prunus-patch-2026-event","event_type":"experimental_scope_comparison","label":"The shikimic-acid-prunus-patch-2026 record is a distinct-compound or preparation comparison; its biological effects are not assigned to isolated shikimic acid.","description":"**A mixed patch does not isolate shikimic acid efficacy.** The same report studied patches containing 0.5% shikimic acid and 0.5% P. mume extract plus additional formulation constituents in 15 volunteers aged 18–28. It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"67ad4a8f-1bf6-59e5-90a6-97b7709024d3","slug":"shikimic-acid","display_name":"Shikimic acid","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"efeb7652-8fe6-5ac9-a77f-ec49c8e6bf24","slug":"shikimic-acid-prunus-patch-2026","display_name":"2026 mixed shikimic-acid/Prunus-mume acne patch","entity_type_key":"chemical_species"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full-text methods/results reviewed. 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It was open-label, nonrandomized and split-body, over 48 h. Sebum decreased with both this patch and a 0.5% salicylic-acid comparator; the between-patch difference was not significant (p=0.12). No adverse skin effects were reported in this small short study. It does not establish isolated shikimic acid efficacy, long-term safety, oral antiandrogen action or synergy. [Novel prospectives of shikimic acid and Prunus mume extract for enhancing bioactivity on 5α-reductase and stability in cosmetic patches for acne treatment](https://www.frontiersin.org/journals/natural-products/articles/10.3389/fntpr.2025.1737986/full)","model_system":"Editorial identity/scope connection, not experimental causation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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