{"id":"2991ceda-f6db-59ca-81bd-33b43f76271f","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-ldl-low-dose","predicate":"reduces","statement":"The tested high-molecular-weight DE70 citrus pectins at 6 g/day lowered LDL by approximately 6-7%.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"5e10e6a9-158e-5d79-bc2c-e85818e20b8d","mechanism_event_label":"The trial also found an LDL response at its lower tested regimen.","subject":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"object":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"5e10e6a9-158e-5d79-bc2c-e85818e20b8d","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-ldl-low-dose-event","event_type":"observed_intervention","label":"The trial also found an LDL response at its lower tested regimen.","description":"The tested high-molecular-weight DE70 citrus pectins at 6 g/day lowered LDL by approximately 6-7%.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d3a1b93d-0a2c-5d1b-b672-5e4ef4b09a10","slug":"cholesterol","display_name":"Cholesterol","entity_type_key":"lipid"},"role":"measured_lipid","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/22190137.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"20212c2dcb0b2018c37d0eac06932c1ec9da0a9d514bb3bd905f476594b32611\", \"start_char\": 0, \"end_char\": 1601, \"text_sha256\": \"20212c2dcb0b2018c37d0eac06932c1ec9da0a9d514bb3bd905f476594b32611\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized crossover comparisons of pectin preparations","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"15 g/day for four weeks; additional high-MW citrus preparation at 6 g/day for three weeks; cellulose comparator","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Preparation-specific lipid surrogates; no cardiovascular event outcome. Methylesterification alone did not explain every preparation difference.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The trial also found an LDL response at its lower tested regimen.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-p22190137] Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. (2012). https://pubmed.ncbi.nlm.nih.gov/22190137/ DOI: 10.1038/ejcn.2011.208","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Circulating lipids","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9c11b5cf-1485-5c59-b4a0-9ba1d060ca1a","evidence_kind":"source_excerpt","locator":"Lines 789-800","start_line":789,"end_line":800,"excerpt":"### pectin-ldl-low-dose\nThe tested high-molecular-weight DE70 citrus pectins at 6 g/day lowered LDL by approximately 6-7%.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The trial also found an LDL response at its lower tested regimen.\norganism: Homo sapiens\ntissue_or_cell_type: Circulating lipids\nexperimental_model: Randomized crossover comparisons of pectin preparations\nlimitations: Preparation-specific lipid surrogates; no cardiovascular event outcome. Methylesterification alone did not explain every preparation difference.\nexposure: 15 g/day for four weeks; additional high-MW citrus preparation at 6 g/day for three weeks; cellulose comparator\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/22190137.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"20212c2dcb0b2018c37d0eac06932c1ec9da0a9d514bb3bd905f476594b32611\", \"start_char\": 0, \"end_char\": 1601, \"text_sha256\": \"20212c2dcb0b2018c37d0eac06932c1ec9da0a9d514bb3bd905f476594b32611\"}\n[pectin-p22190137] Cholesterol-lowering properties of different pectin types in mildly hyper-cholesterolemic men and women. 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