{"id":"2980fbf7-98f4-5b77-8949-9e7e3c1bdc7d","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-pk-six","predicate":"has_measured_bioavailability","statement":"Estimated oral bioavailability was 68 ± 9% after 6 g in eight healthy men.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2e5aa5e5-b06f-5bdc-8ee2-a15b63ca8c09","mechanism_event_label":"The administered dose and the amount reaching circulation differ.","subject":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"object":{"id":"95843b11-d77b-5ef6-8394-80d62b0620c8","slug":"arginine-oral-bioavailability","display_name":"Absolute oral arginine bioavailability","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2e5aa5e5-b06f-5bdc-8ee2-a15b63ca8c09","stable_key":"fd37d270-3395-56d6-9f1c-ddda56e606f6:arg-pk-six-event","event_type":"observed_relationship","label":"The administered dose and the amount reaching circulation differ.","description":"Estimated oral bioavailability was 68 ± 9% after 6 g in eight healthy men.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"eeca3c9e-7749-5677-b7bd-37fe8f7c228d","slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"95843b11-d77b-5ef6-8394-80d62b0620c8","slug":"arginine-oral-bioavailability","display_name":"Absolute oral arginine bioavailability","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Oral 6 g, intravenous 6/30 g and placebo comparisons.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Study-specific estimate; another study using 10 g reported approximately 20%. Different dose and analysis prevent treating either as a universal constant.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Arginine collection; tissue, species, dose and formulation distinctions retained.","comparator":null,"unit":null,"notes":"","entity":{"slug":"arginine","display_name":"L-Arginine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The administered dose and the amount reaching circulation differ.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"L-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9833603/ · DOI 10.1046/j.1365-2125.1998.00803.x","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c4048586-1262-523e-92da-ae6c2b2994e6","evidence_kind":"source_excerpt","locator":"Lines 342-348","start_line":342,"end_line":348,"excerpt":"## arg-pk-six\nThe administered dose and the amount reaching circulation differ.\nEstimated oral bioavailability was 68 ± 9% after 6 g in eight healthy men.\nModel: Oral 6 g, intravenous 6/30 g and placebo comparisons.\nLimitations: Study-specific estimate; another study using 10 g reported approximately 20%. Different dose and analysis prevent treating either as a universal constant.\nEvidence access: Primary abstract\nL-arginine-induced vasodilation in healthy humans: pharmacokinetic-pharmacodynamic relationship. · 1998 · https://pubmed.ncbi.nlm.nih.gov/9833603/ · DOI 10.1046/j.1365-2125.1998.00803.x","model_system":"Oral 6 g, intravenous 6/30 g and placebo comparisons.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; primary evidence access stated per claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"bb9a67ea-904f-5b8a-93a4-459081212bdd","stable_key":"import-fd37d270-3395-56d6-9f1c-ddda56e606f6","title":"L-Arginine: transport, metabolic branches, nutrient interactions, availability and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"ec0e9a3fb72b7485534e4372a074ac7624a399ff962e55690eb462217b5149ec","revision_id":"af027270-5535-51ae-85ff-9c76c518c962","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}