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(2017). https://pubmed.ncbi.nlm.nih.gov/27335120/ DOI: 10.1681/asn.2016010085","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thick ascending limb and distal nephron","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2b33aa14-05fe-5310-953c-da5a88337f28","evidence_kind":"source_excerpt","locator":"Lines 913-924","start_line":913,"end_line":924,"excerpt":"### chloride-clcnk2-basolateral\nKnockout patch-clamp studies identified ClC-K2 as a major basolateral chloride channel in the tested nephron segments.\nCondition category: normal\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Chloride needs a route out of the back of kidney cells as well as a route in.\norganism: Mouse\ntissue_or_cell_type: Thick ascending limb and distal nephron\nexperimental_model: Clcnk2 knockout and nephron patch clamp\nlimitations: Mouse ortholog; not a claim of dietary chloride deficiency.\nexposure: Gene deletion; furosemide/thiazide responses\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/27335120.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"0a0a14e0cc6fd76c451f92665dfed0255edcaf0355b46414f91c74d977f5d6b3\", \"start_char\": 0, \"end_char\": 1432, \"text_sha256\": \"0a0a14e0cc6fd76c451f92665dfed0255edcaf0355b46414f91c74d977f5d6b3\"}\n[chloride-p27335120] The ClC-K2 Chloride Channel Is Critical for Salt Handling in the Distal Nephron. 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