{"id":"29765613-c66b-5544-b243-098f6efc30d7","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-precursor-absolute-synthesis","predicate":"increases","statement":"The absolute erythrocyte GSH synthesis rate increased 230.9% after supplementation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f4bd4410-0fc5-5d9d-abbf-47156c6396da","mechanism_event_label":"The measured amount produced also increased.","subject":{"id":"e95551e8-ac0d-5b44-b374-b2e0cdffccdb","slug":"glynac-2011","display_name":"Glycine plus cysteine-precursor supplementation in the 2011 tracer study","entity_type_key":"chemical_species"},"object":{"id":"c5a4af5d-3875-58d5-9e8c-60fcf2cfa58a","slug":"rbc-gsh-absolute-synthesis-rate","display_name":"Human erythrocyte absolute glutathione synthesis rate","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f4bd4410-0fc5-5d9d-abbf-47156c6396da","stable_key":"db0fc92e-b5ef-5667-a4c5-3ef257edbc9b:glutathione-precursor-absolute-synthesis-event","event_type":"observed_intervention","label":"The measured amount produced also increased.","description":"The absolute erythrocyte GSH synthesis rate increased 230.9% after supplementation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"2b507258-430c-51fe-9fd2-e510c2c197a9","slug":"glycine","display_name":"Glycine","entity_type_key":"small_molecule"},"role":"supplemented_precursor","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b5fa7a22-e5a7-58d9-9e39-91a611aa431e","slug":"n-acetylcysteine","display_name":"N-Acetyl-L-cysteine","entity_type_key":"small_molecule"},"role":"cysteine_precursor","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e95551e8-ac0d-5b44-b374-b2e0cdffccdb","slug":"glynac-2011","display_name":"Glycine plus cysteine-precursor supplementation in the 2011 tracer study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c5a4af5d-3875-58d5-9e8c-60fcf2cfa58a","slug":"rbc-gsh-absolute-synthesis-rate","display_name":"Human erythrocyte absolute glutathione synthesis rate","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/glutathione-research/21795440.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"97479748f2fecc462981498968c43dd6199dcdb9c7f91a2118d98695fc0087dd\", \"start_char\": 0, \"end_char\": 2139, \"text_sha256\": \"97479748f2fecc462981498968c43dd6199dcdb9c7f91a2118d98695fc0087dd\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Stable-isotope tracer study with before/after supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Two weeks of glycine/cysteine-precursor supplementation in older participants","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small non-placebo-controlled intervention; age comparison and treatment response are not universal aging rules.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Glutathione research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutathione","display_name":"GSH","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The measured amount produced also increased.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[glutathione-p21795440] Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. (2011). https://pubmed.ncbi.nlm.nih.gov/21795440/ DOI: 10.3945/ajcn.110.003483","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Eight older and eight younger adults; erythrocytes","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"8326a401-25c7-5591-9033-668000133376","evidence_kind":"source_excerpt","locator":"Lines 1113-1124","start_line":1113,"end_line":1124,"excerpt":"### glutathione-precursor-absolute-synthesis\nThe absolute erythrocyte GSH synthesis rate increased 230.9% after supplementation.\nCondition category: nutrient_deficiency\nnutrient_topic: Glutathione research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The measured amount produced also increased.\norganism: Human\ntissue_or_cell_type: Eight older and eight younger adults; erythrocytes\nexperimental_model: Stable-isotope tracer study with before/after supplementation\nlimitations: Small non-placebo-controlled intervention; age comparison and treatment response are not universal aging rules.\nexposure: Two weeks of glycine/cysteine-precursor supplementation in older participants\nevidence_span: {\"source_cache\": \"artifacts/glutathione-research/21795440.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"97479748f2fecc462981498968c43dd6199dcdb9c7f91a2118d98695fc0087dd\", \"start_char\": 0, \"end_char\": 2139, \"text_sha256\": \"97479748f2fecc462981498968c43dd6199dcdb9c7f91a2118d98695fc0087dd\"}\n[glutathione-p21795440] Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. (2011). https://pubmed.ncbi.nlm.nih.gov/21795440/ DOI: 10.3945/ajcn.110.003483","model_system":"Stable-isotope tracer study with before/after supplementation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [glutathione-p21795440] Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation. (2011). https://pubmed.ncbi.nlm.nih.gov/21795440/ DOI: 10.3945/ajcn.110.003483","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9b7417fd-059d-5683-b452-71d1e3cf82d0","stable_key":"import-db0fc92e-b5ef-5667-a4c5-3ef257edbc9b","title":"Glutathione: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"2a5740c4a7e770aafe883fea47909b18bf5e174f211749935130a50f9dea2753","revision_id":"a64016dd-4b72-5954-a72d-0e61de854073","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}