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(2025). https://pubmed.ncbi.nlm.nih.gov/39806024/ DOI: 10.1038/s41594-024-01462-9","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Synaptic-vesicle transporter","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6ebc9373-0d16-5f84-a8d1-4db63a7c7ee6","evidence_kind":"source_excerpt","locator":"Lines 438-449","start_line":438,"end_line":449,"excerpt":"### choline-vacht-packaging\nVAChT recognizes acetylcholine and packages it into vesicles for subsequent release.\nCondition category: normal\nnutrient_topic: Choline research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Making acetylcholine and loading it into a release vesicle are separate steps.\norganism: Human VAChT protein\ntissue_or_cell_type: Synaptic-vesicle transporter\nexperimental_model: Human VAChT cryo-EM in apo, substrate-bound and inhibitor-bound states\nlimitations: Packaging is distinct from synthesis and release. Structures support substrate recognition and protonation coupling, not a clinical effect of choline supplementation.\nexposure: Acetylcholine and vesamicol ligand binding\nevidence_span: {\"source_cache\": \"artifacts/choline-research/39806024.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e2c63d42f1864e1d9401293ec0c67d659eca8dbb0d571a8d1a328ec04883eb78\", \"start_char\": 0, \"end_char\": 1047, \"text_sha256\": \"e2c63d42f1864e1d9401293ec0c67d659eca8dbb0d571a8d1a328ec04883eb78\"}\n[choline-p39806024] Binding mechanism and antagonism of the vesicular acetylcholine transporter VAChT. (2025). https://pubmed.ncbi.nlm.nih.gov/39806024/ DOI: 10.1038/s41594-024-01462-9","model_system":"Human VAChT cryo-EM in apo, substrate-bound and inhibitor-bound states","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [choline-p39806024] Binding mechanism and antagonism of the vesicular acetylcholine transporter VAChT. (2025). https://pubmed.ncbi.nlm.nih.gov/39806024/ DOI: 10.1038/s41594-024-01462-9","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"0ba2f05e-5cf5-5bd7-ae5d-0ab4945fcb7b","stable_key":"import-27e0c1cf-7726-5164-8b15-27a631584cd0","title":"Choline: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"c7afe3d579eba0df6d2a4c26699c653462749e03188348f900c07748cc7282a8","revision_id":"0fa7b48f-2a3c-5adc-b13e-48727dd6f815","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}