{"id":"29570eb7-888f-5f29-9578-eeeb50b162d3","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-toxicity-case-recovery","predicate":"dose_reduction_accompanied_case_recovery","statement":"After long-term 1250–1750 mg/day exposure, the reported patient recovered sensory function and nerve potentials following reduction to 500 mg/day.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"dadaa928-4338-5366-ac8f-7db5e06a4361","mechanism_event_label":"Recovery was possible in this individual despite long exposure.","subject":{"id":"aa6648f2-8962-5567-9939-ef4145e40ed1","slug":"pyridoxine","display_name":"Pyridoxine","entity_type_key":"small_molecule"},"object":{"id":"77b81275-d0fb-5f84-a963-1c93614b204f","slug":"sensory-neuropathy","display_name":"Sensory neuropathy","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"dadaa928-4338-5366-ac8f-7db5e06a4361","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-toxicity-case-recovery-event","event_type":"observed_intervention","label":"Recovery was possible in this individual despite long exposure.","description":"After long-term 1250–1750 mg/day exposure, the reported patient recovered sensory function and nerve potentials following reduction to 500 mg/day.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d728b2a6-7e08-5036-b13b-620ad1b8e171","slug":"sensory-nerve-action-potentials","display_name":"Sensory nerve action potentials","entity_type_key":"cellular_process"},"role":"recovery_measure","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"aa6648f2-8962-5567-9939-ef4145e40ed1","slug":"pyridoxine","display_name":"Pyridoxine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"77b81275-d0fb-5f84-a963-1c93614b204f","slug":"sensory-neuropathy","display_name":"Sensory neuropathy","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"Single patient with homocystinuria and long-term high-dose pyridoxine exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"1250–1750 mg/day for 20 years; subsequently reduced to 500 mg/day. Case history, not evidence that the reduced dose is safe generally.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Single homocystinuria case; does not establish universal reversibility or safety of 500 mg/day. The article background statement about 50 mg is not treated as an experimentally determined threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Recovery was possible in this individual despite long exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-echanizlaguna2018] Regressive pyridoxine-induced sensory neuronopathy in a patient with homocystinuria (2018). https://pubmed.ncbi.nlm.nih.gov/29954767/ DOI: 10.1136/bcr-2018-225059","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Peripheral sensory nerves","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dabf1aef-601f-5a4c-8d22-77d16bf5b9d1","evidence_kind":"source_excerpt","locator":"Lines 1596-1606","start_line":1596,"end_line":1606,"excerpt":"### b6-toxicity-case-recovery\nAfter long-term 1250–1750 mg/day exposure, the reported patient recovered sensory function and nerve potentials following reduction to 500 mg/day.\nCondition category: normal\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Recovery was possible in this individual despite long exposure.\norganism: Homo sapiens\ntissue_or_cell_type: Peripheral sensory nerves\nexperimental_model: Single patient with homocystinuria and long-term high-dose pyridoxine exposure.\nlimitations: Single homocystinuria case; does not establish universal reversibility or safety of 500 mg/day. The article background statement about 50 mg is not treated as an experimentally determined threshold.\nexposure: 1250–1750 mg/day for 20 years; subsequently reduced to 500 mg/day. Case history, not evidence that the reduced dose is safe generally.\n[b6-echanizlaguna2018] Regressive pyridoxine-induced sensory neuronopathy in a patient with homocystinuria (2018). https://pubmed.ncbi.nlm.nih.gov/29954767/ DOI: 10.1136/bcr-2018-225059","model_system":"Single patient with homocystinuria and long-term high-dose pyridoxine exposure.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-echanizlaguna2018] Regressive pyridoxine-induced sensory neuronopathy in a patient with homocystinuria (2018). https://pubmed.ncbi.nlm.nih.gov/29954767/ DOI: 10.1136/bcr-2018-225059","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}