{"id":"2950c179-fed3-51a6-9304-cbc8ce4f7fc9","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:selective-mg-depletion-lowers-circulating-calcium","predicate":"depletion-lowers","statement":"Three weeks of selective Mg depletion produced a small but significant reduction in serum calcium in the adult study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9e8dd3fa-9a7a-53e1-8319-e70a25126d75","mechanism_event_label":"Calcium regulation changed during experimental Mg shortage even without a preceding calcium-repletion failure.","subject":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"object":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9e8dd3fa-9a7a-53e1-8319-e70a25126d75","stable_key":"0f17db03-207f-5910-ac8e-13dfc2f378ce:selective-mg-depletion-lowers-circulating-calcium-event","event_type":"biochemical_relationship","label":"Calcium regulation changed during experimental Mg shortage even without a preceding calcium-repletion failure.","description":"Three weeks of selective Mg depletion produced a small but significant reduction in serum calcium in the adult study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8e2a5a1f-cd49-5f28-8611-325266fb78a6","slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"},"role":"affected nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e162b0ab-1449-5471-b3c3-4638a0fa3a96","slug":"pth","display_name":"Parathyroid hormone / PTH","entity_type_key":"protein"},"role":"associated regulatory signal","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1f0c42f0-eaf3-5b86-966d-7ffc8a84872b","slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"068b1eb6-c8bf-59d3-98a0-df623ad01b52","slug":"serum-calcium-concentration","display_name":"Serum calcium concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"magnesium -> calcium","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"26 initially normal adults before/after three-week low-Mg diet","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mean change in a small controlled study; not evidence that every mildly low Mg value causes clinical hypocalcemia.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Magnesium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"magnesium","display_name":"Magnesium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Calcium regulation changed during experimental Mg shortage even without a preceding calcium-repletion failure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[fatemi-1991-selective-depletion] Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. (1991). https://pubmed.ncbi.nlm.nih.gov/1939521/ DOI: 10.1210/jcem-73-5-1067","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Blood; parathyroid and renal mineral axis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"3c6f1df6-659c-58c2-aa5a-9ba3ee3a0aa4","evidence_kind":"source_excerpt","locator":"Lines 373-383","start_line":373,"end_line":383,"excerpt":"### selective-mg-depletion-lowers-circulating-calcium\nThree weeks of selective Mg depletion produced a small but significant reduction in serum calcium in the adult study.\nCondition category: nutrient_deficiency\nnutrient_topic: Magnesium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Calcium regulation changed during experimental Mg shortage even without a preceding calcium-repletion failure.\norganism: Homo sapiens\ntissue_or_cell_type: Blood; parathyroid and renal mineral axis\nexperimental_model: 26 initially normal adults before/after three-week low-Mg diet\nlimitations: Mean change in a small controlled study; not evidence that every mildly low Mg value causes clinical hypocalcemia.\ncross_nutrient: magnesium -> calcium\n[fatemi-1991-selective-depletion] Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. (1991). https://pubmed.ncbi.nlm.nih.gov/1939521/ DOI: 10.1210/jcem-73-5-1067","model_system":"26 initially normal adults before/after three-week low-Mg diet","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [fatemi-1991-selective-depletion] Effect of experimental human magnesium depletion on parathyroid hormone secretion and 1,25-dihydroxyvitamin D metabolism. (1991). https://pubmed.ncbi.nlm.nih.gov/1939521/ DOI: 10.1210/jcem-73-5-1067","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dd101e28-1a2e-5a48-9d1e-809c77514866","stable_key":"import-0f17db03-207f-5910-ac8e-13dfc2f378ce","title":"Magnesium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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