{"id":"29325e76-9fd5-58c0-8048-67f49170fb5c","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-human-ovary-ra-response","predicate":"promotes","statement":"RA increased meiotic cells in developmentally competent human fetal ovarian cultures.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"fb920908-ab91-59ff-8148-734f3246f2a9","mechanism_event_label":"The human ovarian response depends on developmental readiness.","subject":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"object":{"id":"3aaff75a-77e2-56e2-a26f-cafe43517b52","slug":"human-fetal-ovarian-meiotic-initiation","display_name":"Human fetal ovarian meiotic initiation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fb920908-ab91-59ff-8148-734f3246f2a9","stable_key":"3c852f36-7951-5fd9-9013-d771a8d16d8a:va-repro-human-ovary-ra-response-event","event_type":"biochemical_relationship","label":"The human ovarian response depends on developmental readiness.","description":"RA increased meiotic cells in developmentally competent human fetal ovarian cultures.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"05487b29-8c59-5af8-83cf-cf9c79c5ecb8","slug":"all-trans-retinoic-acid","display_name":"All-trans-retinoic acid","entity_type_key":"small_molecule"},"role":"experimental_ligand","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"3aaff75a-77e2-56e2-a26f-cafe43517b52","slug":"human-fetal-ovarian-meiotic-initiation","display_name":"Human fetal ovarian meiotic initiation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Fetal ovarian organ culture","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Meiotic entry examined in 10-11-week-post-fertilization ovaries; exact RA dose/time unavailable in abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Ovaries at 8 weeks post fertilization or earlier did not enter meiosis simply with RA and serum.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-a","display_name":"Vitamin A","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The human ovarian response depends on developmental readiness.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[human2010] Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis. (2010). https://pubmed.ncbi.nlm.nih.gov/20670969/ DOI: 10.1093/humrep/deq195","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"human fetal ovary","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7264d683-b9e5-5b15-b147-170baaf2d195","evidence_kind":"source_excerpt","locator":"Lines 356-367","start_line":356,"end_line":367,"excerpt":"### va-repro-human-ovary-ra-response\nRA increased meiotic cells in developmentally competent human fetal ovarian cultures.\nCondition category: normal\nnutrient_topic: Vitamin A expansion research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The human ovarian response depends on developmental readiness.\norganism: Homo sapiens\ntissue_or_cell_type: human fetal ovary\nexperimental_model: Fetal ovarian organ culture\nlimitations: Ovaries at 8 weeks post fertilization or earlier did not enter meiosis simply with RA and serum.\nexposure: Meiotic entry examined in 10-11-week-post-fertilization ovaries; exact RA dose/time unavailable in abstract.\ncross_nutrient: false\n[human2010] Meiosis initiation in the human ovary requires intrinsic retinoic acid synthesis. 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