{"id":"2918835c-38e9-5ac7-ad46-3173446cb8bb","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-renal-mg","predicate":"reduces","statement":"Magnesium reabsorption fell from 97.0% to 94.2%, with no significant change in filtered magnesium load.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"c123894f-ff7a-5302-b985-8686f5a066e3","mechanism_event_label":"The kidneys retained a smaller fraction of the filtered mineral.","subject":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"object":{"id":"66e1e9be-15e3-5431-9f49-b07ae3a99b5a","slug":"renal-magnesium-reabsorption","display_name":"Renal magnesium reabsorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c123894f-ff7a-5302-b985-8686f5a066e3","stable_key":"ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6:caf-renal-mg-event","event_type":"observed_relationship","label":"The kidneys retained a smaller fraction of the filtered mineral.","description":"Magnesium reabsorption fell from 97.0% to 94.2%, with no significant change in filtered magnesium load.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ef028472-7c33-583d-b52e-40676004d370","slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"66e1e9be-15e3-5431-9f49-b07ae3a99b5a","slug":"renal-magnesium-reabsorption","display_name":"Renal magnesium reabsorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"bff427ab-35f9-59c2-bb24-fd5953bbaec2","slug":"magnesium-ion","display_name":"Mg2+","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"37 women, age 31–78; decaffeinated beverage with or without caffeine 6 mg/kg lean body mass; two-hour urine collection.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Acute renal handling. The exact tubular mechanism was unresolved; no long-term deficiency, bone loss or replacement requirement measured.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Caffeine collection; salts, coffee, species and coexposure contexts retain their identities.","comparator":null,"unit":null,"notes":"","entity":{"slug":"caffeine","display_name":"Caffeine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The kidneys retained a smaller fraction of the filtered mineral.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of dietary caffeine on renal handling of minerals in adult women. · 1990 · https://pubmed.ncbi.nlm.nih.gov/2402180/ · DOI 10.1016/0024-3205(90)90616-y","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"17f22665-371b-55b7-a0e1-eb38b3ef1c78","evidence_kind":"source_excerpt","locator":"Lines 292-298","start_line":292,"end_line":298,"excerpt":"## caf-renal-mg\nThe kidneys retained a smaller fraction of the filtered mineral.\nMagnesium reabsorption fell from 97.0% to 94.2%, with no significant change in filtered magnesium load.\nModel: 37 women, age 31–78; decaffeinated beverage with or without caffeine 6 mg/kg lean body mass; two-hour urine collection.\nLimitations: Acute renal handling. The exact tubular mechanism was unresolved; no long-term deficiency, bone loss or replacement requirement measured.\nEvidence access: Primary abstract\nEffects of dietary caffeine on renal handling of minerals in adult women. · 1990 · https://pubmed.ncbi.nlm.nih.gov/2402180/ · DOI 10.1016/0024-3205(90)90616-y","model_system":"37 women, age 31–78; decaffeinated beverage with or without caffeine 6 mg/kg lean body mass; two-hour urine collection.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access stated with the claim.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"40a654db-878c-5471-bc6c-88f4f52599c0","stable_key":"import-ea2f0904-ab2c-5d1e-a3d4-3f7ecdd70cd6","title":"Caffeine: receptors, metabolism, nutrient interactions, adaptation and discovery questions (2026-09-18)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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