{"id":"2908a30e-64ad-5a52-bd8b-4700bef9d91b","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-adams-circulating-hcap-null","predicate":"does-not-detectably-change","statement":"The patient D2 supplementation course did not change circulating hCAP concentration, despite improved serum support for the ex-vivo transcript response.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"49e0271f-450c-56cb-97a9-122068dd65be","mechanism_event_label":"A better local cell response did not translate into a higher circulating protein measurement.","subject":{"id":"6e1cf31c-f78e-596b-b1b3-70585cf9c948","slug":"ergocalciferol","display_name":"Ergocalciferol / vitamin D2","entity_type_key":"small_molecule"},"object":{"id":"ae4a194f-f53b-5993-a3d1-5c4a77873932","slug":"circulating-hcap18-concentration","display_name":"Circulating hCAP18 concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"49e0271f-450c-56cb-97a9-122068dd65be","stable_key":"1deb434a-3547-51a0-a038-87b1ce79ec38:vd-adams-circulating-hcap-null-event","event_type":"observed_intervention","label":"A better local cell response did not translate into a higher circulating protein measurement.","description":"The patient D2 supplementation course did not change circulating hCAP concentration, despite improved serum support for the ex-vivo transcript response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6e1cf31c-f78e-596b-b1b3-70585cf9c948","slug":"ergocalciferol","display_name":"Ergocalciferol / vitamin D2","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ae4a194f-f53b-5993-a3d1-5c4a77873932","slug":"circulating-hcap18-concentration","display_name":"Circulating hCAP18 concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"false","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human bone-clinic cohort and ex-vivo monocytes in 10% autologous serum","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"D2 treatment and paired circulating hCAP assay in the bone-clinic cohort.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Circulating protein and stimulated local transcription are different readouts, so this is not a contradiction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-d","display_name":"Vitamin D2 and D3","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A better local cell response did not translate into a higher circulating protein measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[adams2009] Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. (2009). https://pubmed.ncbi.nlm.nih.gov/19299728/ DOI: 10.4049/jimmunol.0803736","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human serum","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ce8c6b20-74fc-50a5-b265-ae741adccefc","evidence_kind":"source_excerpt","locator":"Lines 1022-1033","start_line":1022,"end_line":1033,"excerpt":"### vd-adams-circulating-hcap-null\nThe patient D2 supplementation course did not change circulating hCAP concentration, despite improved serum support for the ex-vivo transcript response.\nCondition category: normal\nnutrient_topic: Vitamin D2 and D3 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A better local cell response did not translate into a higher circulating protein measurement.\norganism: Homo sapiens\ntissue_or_cell_type: Human serum\nexperimental_model: Human bone-clinic cohort and ex-vivo monocytes in 10% autologous serum\nlimitations: Circulating protein and stimulated local transcription are different readouts, so this is not a contradiction.\nexposure: D2 treatment and paired circulating hCAP assay in the bone-clinic cohort.\ncross_nutrient: false\n[adams2009] Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. (2009). https://pubmed.ncbi.nlm.nih.gov/19299728/ DOI: 10.4049/jimmunol.0803736","model_system":"Human bone-clinic cohort and ex-vivo monocytes in 10% autologous serum","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [adams2009] Vitamin d-directed rheostatic regulation of monocyte antibacterial responses. (2009). https://pubmed.ncbi.nlm.nih.gov/19299728/ DOI: 10.4049/jimmunol.0803736","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c95c763c-5b31-5b3f-a2f8-2dfe5ef0d3ca","stable_key":"import-1deb434a-3547-51a0-a038-87b1ce79ec38","title":"Vitamin D2 and D3: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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