{"id":"28d3b8a7-96f2-5d38-bab7-6e9c381e3a71","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-cud-iron-absorption","predicate":"deficiency_reduces","statement":"Copper-deficient male and female rats absorbed about 60% and 70%, respectively, of the iron absorbed by copper-adequate controls.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"77459768-8533-502b-b104-749092c80a47","mechanism_event_label":"Adding iron alone does not describe the copper-dependent processing step.","subject":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"object":{"id":"1d002d76-731c-5eb6-9f2c-a19133462ff4","slug":"rat-intestinal-iron-absorption","display_name":"Rat intestinal iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"77459768-8533-502b-b104-749092c80a47","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-cud-iron-absorption-event","event_type":"biochemical_relationship","label":"Adding iron alone does not describe the copper-dependent processing step.","description":"Copper-deficient male and female rats absorbed about 60% and 70%, respectively, of the iron absorbed by copper-adequate controls.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"affected nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1d002d76-731c-5eb6-9f2c-a19133462ff4","slug":"rat-intestinal-iron-absorption","display_name":"Rat intestinal iron absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/15623839.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5e3723e4fdd961caf66979e26614d98cbfbd65f38ba48232428e5302c054c3ac\", \"start_char\": 0, \"end_char\": 1613, \"text_sha256\": \"5e3723e4fdd961caf66979e26614d98cbfbd65f38ba48232428e5302c054c3ac\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Controlled copper-deficient versus adequate diets with radiolabeled iron","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Less than 0.3 versus 5 mg copper/kg diet; male and female weanlings","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Animal depletion regimens are not human thresholds. Iron redistribution differed by sex.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Rat","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding iron alone does not describe the copper-dependent processing step.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p15623839] Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. (2005). https://pubmed.ncbi.nlm.nih.gov/15623839/ DOI: 10.1093/jn/135.1.92","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Duodenal enterocytes and whole-body iron","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"e949774b-3c2f-5a45-a7f1-04d706c53994","evidence_kind":"source_excerpt","locator":"Lines 871-882","start_line":871,"end_line":882,"excerpt":"### copper-cud-iron-absorption\nCopper-deficient male and female rats absorbed about 60% and 70%, respectively, of the iron absorbed by copper-adequate controls.\nCondition category: nutrient_deficiency\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Adding iron alone does not describe the copper-dependent processing step.\norganism: Rat\ntissue_or_cell_type: Duodenal enterocytes and whole-body iron\nexperimental_model: Controlled copper-deficient versus adequate diets with radiolabeled iron\nlimitations: Animal depletion regimens are not human thresholds. Iron redistribution differed by sex.\nexposure: Less than 0.3 versus 5 mg copper/kg diet; male and female weanlings\nevidence_span: {\"source_cache\": \"artifacts/copper-research/15623839.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5e3723e4fdd961caf66979e26614d98cbfbd65f38ba48232428e5302c054c3ac\", \"start_char\": 0, \"end_char\": 1613, \"text_sha256\": \"5e3723e4fdd961caf66979e26614d98cbfbd65f38ba48232428e5302c054c3ac\"}\n[copper-p15623839] Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. (2005). https://pubmed.ncbi.nlm.nih.gov/15623839/ DOI: 10.1093/jn/135.1.92","model_system":"Controlled copper-deficient versus adequate diets with radiolabeled iron","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p15623839] Dietary copper deficiency reduces iron absorption and duodenal enterocyte hephaestin protein in male and female rats. (2005). https://pubmed.ncbi.nlm.nih.gov/15623839/ DOI: 10.1093/jn/135.1.92","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"84b0f62b2dae6835fa26902be87625c003c6c707492d3007e8f9d15420669008","revision_id":"d7e35b8b-3f77-56d9-90b5-5f542c63f321","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}