{"id":"286c11e2-8873-5ae6-8ed7-07a10cc796e4","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-dual-salt-volume","predicate":"cofortification-improves","statement":"Mean thyroid-volume reduction at 40 weeks was 38% with dual iron–iodine salt versus 18% with iodine-only salt (P<0.01).","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"13b579b1-27db-520d-bbe3-c30ef5638003","mechanism_event_label":"Adding iron improved the response to the same amount of iodine in this trial.","subject":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"object":{"id":"ae8b47e9-be28-594e-af38-0a535249e9db","slug":"thyroid-volume","display_name":"Thyroid volume","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"13b579b1-27db-520d-bbe3-c30ef5638003","stable_key":"aaa7baba-8689-56ab-ba1e-b71542bcb8e9:iod-clin-dual-salt-volume-event","event_type":"observed_intervention","label":"Adding iron improved the response to the same amount of iodine in this trial.","description":"Mean thyroid-volume reduction at 40 weeks was 38% with dual iron–iodine salt versus 18% with iodine-only salt (P<0.01).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0e0ac6d1-3336-506a-9f69-5838ca1500ed","slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"},"role":"iodine supplied equally","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f20cb550-cb6b-5eab-a4d7-27537a5eb14b","slug":"ferrous-sulfate","display_name":"Ferrous sulfate","entity_type_key":"chemical_species"},"role":"iron preparation","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2d1c1d41-eea1-5a33-9312-e1e94bcb2a15","slug":"iodized-salt","display_name":"Iodized salt preparation","entity_type_key":"chemical_species"},"role":"fortified food","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"ae8b47e9-be28-594e-af38-0a535249e9db","slug":"thyroid-volume","display_name":"Thyroid volume","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"cross_nutrient","value_text":"true","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_location","value_text":"Primary indexed abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Nine-month randomized double-blind controlled trial in 377 goitrous children aged 6–15 with high anemia prevalence","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Iodized salt 25 micrograms iodine/g versus dual-fortified salt with the same iodine plus 1 mg iron/g as microencapsulated ferrous sulfate; 40-week measurements.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Clinical intervention and thyroid endpoints do not identify the exact iron-dependent step. Iodized-salt-only participants also improved. Related publications from this cohort are not independent trials.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Iodine research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"iodine","display_name":"Iodine","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Adding iron improved the response to the same amount of iodine in this trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[iod-clin-zimmer2002] Addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous, iron-deficient children: a randomized, double-blind, controlled trial. (2002). https://pubmed.ncbi.nlm.nih.gov/12457449/ DOI: 10.1530/eje.0.1470747","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Thyroid volume, circulating thyroxine and iron indices","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"15787ccc-1bc5-5ce7-ac75-bcb93cdd4b15","evidence_kind":"source_excerpt","locator":"Lines 1230-1242","start_line":1230,"end_line":1242,"excerpt":"### iod-clin-dual-salt-volume\nMean thyroid-volume reduction at 40 weeks was 38% with dual iron–iodine salt versus 18% with iodine-only salt (P<0.01).\nCondition category: nutrient_deficiency\nnutrient_topic: Iodine research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Adding iron improved the response to the same amount of iodine in this trial.\norganism: Homo sapiens\ntissue_or_cell_type: Thyroid volume, circulating thyroxine and iron indices\nexperimental_model: Nine-month randomized double-blind controlled trial in 377 goitrous children aged 6–15 with high anemia prevalence\nlimitations: Clinical intervention and thyroid endpoints do not identify the exact iron-dependent step. Iodized-salt-only participants also improved. Related publications from this cohort are not independent trials.\nexposure: Iodized salt 25 micrograms iodine/g versus dual-fortified salt with the same iodine plus 1 mg iron/g as microencapsulated ferrous sulfate; 40-week measurements.\ncross_nutrient: true\nevidence_location: Primary indexed abstract.\n[iod-clin-zimmer2002] Addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous, iron-deficient children: a randomized, double-blind, controlled trial. (2002). https://pubmed.ncbi.nlm.nih.gov/12457449/ DOI: 10.1530/eje.0.1470747","model_system":"Nine-month randomized double-blind controlled trial in 377 goitrous children aged 6–15 with high anemia prevalence","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [iod-clin-zimmer2002] Addition of microencapsulated iron to iodized salt improves the efficacy of iodine in goitrous, iron-deficient children: a randomized, double-blind, controlled trial. (2002). https://pubmed.ncbi.nlm.nih.gov/12457449/ DOI: 10.1530/eje.0.1470747","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"76da623d-a34a-5a5c-a942-d7571a85c486","stable_key":"import-aaa7baba-8689-56ab-ba1e-b71542bcb8e9","title":"Iodine: thyroid hormone production, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a4885eb6f58bad4a4514c958b63834619e57b10aa7f694aa97d0f65c7d36548f","revision_id":"ea8001a1-b576-5eda-a193-883c7ad59b73","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}