{"id":"286847e3-de14-5152-a80a-527c52797ead","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-thyroid-combination","predicate":"with_selenomethionine_associated_with_lower","statement":"TSH fell from baseline in the myo-inositol-plus-selenomethionine arm, while no TSH change was reported in the selenomethionine-only arm; the reported TSH P value was a within-group comparison.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"a514716a-0866-50fc-88dc-557631233131","mechanism_event_label":"A thyroid blood marker improved in the combined-treatment group, but these comparisons do not establish a statistical interaction between nutrients.","subject":{"id":"50afe95c-f542-5511-ba8b-c2ff2b037977","slug":"myo-inositol","display_name":"Myo-inositol","entity_type_key":"small_molecule"},"object":{"id":"b2450167-5a3a-5f1d-8933-8b46c25e9dff","slug":"serum-tsh-concentration","display_name":"Serum TSH concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a514716a-0866-50fc-88dc-557631233131","stable_key":"e69ef6a0-0e23-5eac-aca1-cf333781b962:ino-thyroid-combination-event","event_type":"observed_intervention","label":"A thyroid blood marker improved in the combined-treatment group, but these comparisons do not establish a statistical interaction between nutrients.","description":"TSH fell from baseline in the myo-inositol-plus-selenomethionine arm, while no TSH change was reported in the selenomethionine-only arm; the reported TSH P value was a within-group comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"9ae8a163-7137-5610-800b-82ef311e28b9","slug":"selenomethionine","display_name":"Selenomethionine (SeMet)","entity_type_key":"small_molecule"},"role":"shared_intervention","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"50afe95c-f542-5511-ba8b-c2ff2b037977","slug":"myo-inositol","display_name":"Myo-inositol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b2450167-5a3a-5f1d-8933-8b46c25e9dff","slug":"serum-tsh-concentration","display_name":"Serum TSH concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/inositol-research/24224112.fulltext.txt\", \"locator\": \"Exact primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b9b55ed122a2f26149680eb0f4bfab9ea981927754bcbb40305d4697c5d32412\", \"start_char\": 7984, \"end_char\": 8184, \"text_sha256\": \"34e1c5b3fe451ea1278c2adfb27f4977a40d100b82946252ecad03a7879592dc\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind randomized combination trial","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Myo-inositol plus selenomethionine versus selenomethionine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small combination trial without a myo-inositol-only arm. A significant within-group change versus a nonsignificant change in the other arm is not by itself a significant between-group difference or nutrient synergy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Inositol research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"inositol","display_name":"Inositol (stereoisomer family)","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A thyroid blood marker improved in the combined-treatment group, but these comparisons do not establish a statistical interaction between nutrients.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[ino-p24224112] Combined treatment with Myo-inositol and selenium ensures euthyroidism in subclinical hypothyroidism patients with autoimmune thyroiditis. (2013). https://pubmed.ncbi.nlm.nih.gov/24224112/ DOI: 10.1155/2013/424163","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Women with autoimmune subclinical hypothyroidism","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dba0177f-788b-559c-bb38-c44e56d661fe","evidence_kind":"source_excerpt","locator":"Lines 1419-1430","start_line":1419,"end_line":1430,"excerpt":"### ino-thyroid-combination\nTSH fell from baseline in the myo-inositol-plus-selenomethionine arm, while no TSH change was reported in the selenomethionine-only arm; the reported TSH P value was a within-group comparison.\nCondition category: normal\nnutrient_topic: Inositol research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A thyroid blood marker improved in the combined-treatment group, but these comparisons do not establish a statistical interaction between nutrients.\norganism: Homo sapiens\ntissue_or_cell_type: Women with autoimmune subclinical hypothyroidism\nexperimental_model: Double-blind randomized combination trial\nlimitations: Small combination trial without a myo-inositol-only arm. A significant within-group change versus a nonsignificant change in the other arm is not by itself a significant between-group difference or nutrient synergy.\nexposure: Myo-inositol plus selenomethionine versus selenomethionine\nevidence_span: {\"source_cache\": \"artifacts/inositol-research/24224112.fulltext.txt\", \"locator\": \"Exact primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"b9b55ed122a2f26149680eb0f4bfab9ea981927754bcbb40305d4697c5d32412\", \"start_char\": 7984, \"end_char\": 8184, \"text_sha256\": \"34e1c5b3fe451ea1278c2adfb27f4977a40d100b82946252ecad03a7879592dc\"}\n[ino-p24224112] Combined treatment with Myo-inositol and selenium ensures euthyroidism in subclinical hypothyroidism patients with autoimmune thyroiditis. (2013). https://pubmed.ncbi.nlm.nih.gov/24224112/ DOI: 10.1155/2013/424163","model_system":"Double-blind randomized combination trial","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [ino-p24224112] Combined treatment with Myo-inositol and selenium ensures euthyroidism in subclinical hypothyroidism patients with autoimmune thyroiditis. (2013). https://pubmed.ncbi.nlm.nih.gov/24224112/ DOI: 10.1155/2013/424163","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"d590c659-b774-50e6-9f1d-aff61d5f7c9c","stable_key":"import-e69ef6a0-0e23-5eac-aca1-cf333781b962","title":"Inositol: synthesis, signaling, mineral interactions and conditional deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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