{"id":"27a38156-765c-5b67-af03-b31d509aa1af","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-slc25a3-export","predicate":"supports","statement":"Human SLC25A3 expression increased copper export from copper-loaded Lactococcus lactis, supporting an export function.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f6614c3a-25a7-50ff-a8ba-ff90c53a5099","mechanism_event_label":"The carrier can move copper outward as well as support its entry.","subject":{"id":"c37d5788-7e5f-5946-8fc6-1dc7f312a1df","slug":"slc25a3","display_name":"Human mitochondrial phosphate/copper carrier SLC25A3","entity_type_key":"protein"},"object":{"id":"692c9587-12b4-5933-9bc2-395849744467","slug":"mitochondrial-copper-export","display_name":"Copper export across the mitochondrial inner membrane toward the intermembrane space","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f6614c3a-25a7-50ff-a8ba-ff90c53a5099","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-slc25a3-export-event","event_type":"biochemical_relationship","label":"The carrier can move copper outward as well as support its entry.","description":"Human SLC25A3 expression increased copper export from copper-loaded Lactococcus lactis, supporting an export function.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c37d5788-7e5f-5946-8fc6-1dc7f312a1df","slug":"slc25a3","display_name":"Human mitochondrial phosphate/copper carrier SLC25A3","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"692c9587-12b4-5933-9bc2-395849744467","slug":"mitochondrial-copper-export","display_name":"Copper export across the mitochondrial inner membrane toward the intermembrane space","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/42308035.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a172ec9e3d13811a6e6a745d2017398361cc01ec2a06c65065b82ffd06d26d92\", \"start_char\": 0, \"end_char\": 1276, \"text_sha256\": \"a172ec9e3d13811a6e6a745d2017398361cc01ec2a06c65065b82ffd06d26d92\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rat Slc25a3 knockout cardiomyoblasts and human transporter expression in bacteria","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Slc25a3 deletion and elesclomol-copper exposure","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Whole-organelle copper was measured, not separate matrix and intermembrane pools. Matrix trapping is the authors mechanism inferred with transport evidence. This recent study complements import findings; bacterial export does not reproduce mitochondrial topology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human protein in Lactococcus lactis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The carrier can move copper outward as well as support its entry.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p42308035] SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis. (2026). https://pubmed.ncbi.nlm.nih.gov/42308035/ DOI: 10.1073/pnas.2612098123","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Bacterial assay; mitochondrial export is the linked interpretation","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"5f3d0d5f-19eb-54a8-864e-59117712fd66","evidence_kind":"source_excerpt","locator":"Lines 546-557","start_line":546,"end_line":557,"excerpt":"### copper-slc25a3-export\nHuman SLC25A3 expression increased copper export from copper-loaded Lactococcus lactis, supporting an export function.\nCondition category: normal\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The carrier can move copper outward as well as support its entry.\norganism: Human protein in Lactococcus lactis\ntissue_or_cell_type: Bacterial assay; mitochondrial export is the linked interpretation\nexperimental_model: Rat Slc25a3 knockout cardiomyoblasts and human transporter expression in bacteria\nlimitations: Whole-organelle copper was measured, not separate matrix and intermembrane pools. Matrix trapping is the authors mechanism inferred with transport evidence. This recent study complements import findings; bacterial export does not reproduce mitochondrial topology.\nexposure: Slc25a3 deletion and elesclomol-copper exposure\nevidence_span: {\"source_cache\": \"artifacts/copper-research/42308035.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"a172ec9e3d13811a6e6a745d2017398361cc01ec2a06c65065b82ffd06d26d92\", \"start_char\": 0, \"end_char\": 1276, \"text_sha256\": \"a172ec9e3d13811a6e6a745d2017398361cc01ec2a06c65065b82ffd06d26d92\"}\n[copper-p42308035] SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis. (2026). https://pubmed.ncbi.nlm.nih.gov/42308035/ DOI: 10.1073/pnas.2612098123","model_system":"Rat Slc25a3 knockout cardiomyoblasts and human transporter expression in bacteria","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p42308035] SLC25A3 exports mitochondrial copper to metalate cytochrome c oxidase and prevent cuproptosis. (2026). https://pubmed.ncbi.nlm.nih.gov/42308035/ DOI: 10.1073/pnas.2612098123","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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