{"id":"274fd4ad-33e2-5abd-b0c4-072641408462","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:trpv5-loss-renal-reabsorption","predicate":"loss_of_function_reduces","statement":"Trpv5-null mice have impaired distal calcium reabsorption and severe hypercalciuria despite increased vitamin D levels.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"24613b8b-7772-5d81-862d-e563b8820d83","mechanism_event_label":"Hormonal compensation cannot replace the missing channel.","subject":{"id":"ae79ed63-956e-5f19-b2bc-0142bb6e9aea","slug":"trpv5","display_name":"TRPV5","entity_type_key":"protein"},"object":{"id":"9cee0b8f-f680-57b8-aac6-90ed927bd13b","slug":"renal-calcium-reabsorption","display_name":"Renal calcium reabsorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"24613b8b-7772-5d81-862d-e563b8820d83","stable_key":"434e1e27-eb90-583a-956b-62472726ffba:trpv5-loss-renal-reabsorption-event","event_type":"biochemical_relationship","label":"Hormonal compensation cannot replace the missing channel.","description":"Trpv5-null mice have impaired distal calcium reabsorption and severe hypercalciuria despite increased vitamin D levels.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ae79ed63-956e-5f19-b2bc-0142bb6e9aea","slug":"trpv5","display_name":"TRPV5","entity_type_key":"protein"},"role":"deleted_channel","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"reabsorbed_ion","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"9cee0b8f-f680-57b8-aac6-90ed927bd13b","slug":"renal-calcium-reabsorption","display_name":"Renal calcium reabsorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Trpv5 knockout mice; renal micropuncture and oral calcium tracer assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Mouse knockout with micropuncture localization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Calcium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"calcium","display_name":"Calcium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mus musculus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Hormonal compensation cannot replace the missing channel.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[hoenderop2003] Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5 (2003). https://pmc.ncbi.nlm.nih.gov/articles/PMC297001/ DOI: 10.1172/JCI19826","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Early distal convolution","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"35491e38-9c43-5d2a-b75e-b16371fd9a32","evidence_kind":"source_excerpt","locator":"Lines 236-245","start_line":236,"end_line":245,"excerpt":"### trpv5-loss-renal-reabsorption\nTrpv5-null mice have impaired distal calcium reabsorption and severe hypercalciuria despite increased vitamin D levels.\nCondition category: machinery_impairment\nnutrient_topic: Calcium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Hormonal compensation cannot replace the missing channel.\norganism: Mus musculus\ntissue_or_cell_type: Early distal convolution\nexperimental_model: Trpv5 knockout mice; renal micropuncture and oral calcium tracer assays\nlimitations: Mouse knockout with micropuncture localization.\n[hoenderop2003] Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5 (2003). https://pmc.ncbi.nlm.nih.gov/articles/PMC297001/ DOI: 10.1172/JCI19826","model_system":"Trpv5 knockout mice; renal micropuncture and oral calcium tracer assays","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [hoenderop2003] Renal Ca2+ wasting, hyperabsorption, and reduced bone thickness in mice lacking TRPV5 (2003). https://pmc.ncbi.nlm.nih.gov/articles/PMC297001/ DOI: 10.1172/JCI19826","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3c083fa0-59c6-50e9-af42-678d0e3c1006","stable_key":"import-434e1e27-eb90-583a-956b-62472726ffba","title":"Calcium: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"965c934d6b147f2b62f8d45ce6d7a87681a600bfe5c46a585b4704889afd3fc1","revision_id":"543ec48b-4f70-5197-9d76-f5a3c443664c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}