{"id":"268e3225-83d5-58e1-af9b-cb35d82140b6","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-tenapanor-urine","predicate":"changes_excretion","statement":"Tenapanor decreased urinary phosphorus in the four-day healthy-volunteer study.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"731543a8-6c57-5175-bd61-499e73218d47","mechanism_event_label":"The urinary result was consistent with less intestinal absorption, not direct proof of renal-transporter inhibition.","subject":{"id":"b4ff4376-9fb0-5ab7-bdfa-fb7efce7c2b0","slug":"tenapanor","display_name":"Tenapanor","entity_type_key":"small_molecule"},"object":{"id":"fadfdc23-5faa-5f51-afd9-0896fb93f6d1","slug":"urinary-phosphate-excretion","display_name":"Urinary phosphate excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"731543a8-6c57-5175-bd61-499e73218d47","stable_key":"fe6af7fc-7372-5c4f-9c2f-2bbf56695397:phosphorus-tenapanor-urine-event","event_type":"observed_intervention","label":"The urinary result was consistent with less intestinal absorption, not direct proof of renal-transporter inhibition.","description":"Tenapanor decreased urinary phosphorus in the four-day healthy-volunteer study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b4ff4376-9fb0-5ab7-bdfa-fb7efce7c2b0","slug":"tenapanor","display_name":"Tenapanor","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"fadfdc23-5faa-5f51-afd9-0896fb93f6d1","slug":"urinary-phosphate-excretion","display_name":"Urinary phosphate excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/phosphorus-research/30158152.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e\", \"start_char\": 0, \"end_char\": 1701, \"text_sha256\": \"6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rodent physiology, human enteroid transport and healthy-volunteer intervention","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Phosphorus research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"phosphorus","display_name":"Phosphorus","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The urinary result was consistent with less intestinal absorption, not direct proof of renal-transporter inhibition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. (2018). https://pubmed.ncbi.nlm.nih.gov/30158152/ DOI: 10.1126/scitranslmed.aam6474","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestinal epithelium; stool and urinary balance","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"9b7dcf00-4f76-5f3b-a0bf-38a07dc4aaca","evidence_kind":"source_excerpt","locator":"Lines 386-397","start_line":386,"end_line":397,"excerpt":"### phosphorus-tenapanor-urine\nTenapanor decreased urinary phosphorus in the four-day healthy-volunteer study.\nCondition category: normal\nnutrient_topic: Phosphorus research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The urinary result was consistent with less intestinal absorption, not direct proof of renal-transporter inhibition.\norganism: Human\ntissue_or_cell_type: Intestinal epithelium; stool and urinary balance\nexperimental_model: Rodent physiology, human enteroid transport and healthy-volunteer intervention\nlimitations: Tenapanor inhibits NHE3 rather than binding phosphate. TEER is an epithelial assay measure, not a direct clinical permeability score.\nexposure: Enteroid NHE3 perturbation; healthy volunteers 15 mg tenapanor twice daily for four days\nevidence_span: {\"source_cache\": \"artifacts/phosphorus-research/30158152.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e\", \"start_char\": 0, \"end_char\": 1701, \"text_sha256\": \"6e6950931f538331a62ce1a6b35ba66ddf0a6bcaec7fe4b4f8f81e8fd952ee0e\"}\n[phosphorus-p30158152] Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. 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