{"id":"26881618-061d-5624-ac2b-b5e4f5fdf027","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-dose-trial","predicate":"reduces_at_tested_dose","statement":"In a 24-man resistance-trained trial, 3 g/day for 14 days did not change testosterone; 6 g/day lowered total and calculated free testosterone.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"608fd163-49cc-577b-b695-e28e54331ee0","mechanism_event_label":"More was not better in this short dose-comparison trial.","subject":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"object":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"608fd163-49cc-577b-b695-e28e54331ee0","stable_key":"9a47f338-d127-5e4d-abf6-e99056833a69:d-aspartate-human-dose-trial-event","event_type":"observed_relationship","label":"More was not better in this short dose-comparison trial.","description":"In a 24-man resistance-trained trial, 3 g/day for 14 days did not change testosterone; 6 g/day lowered total and calculated free testosterone.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"b3404670-6db1-517f-b9a0-27ecfaac558b","slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dffa79cf-8fea-51e0-8839-6ca30a81cd6a","slug":"circulating-total-testosterone","display_name":"Circulating total testosterone concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e78f545c-d4f7-53a4-b575-56c8fdb8b470","slug":"circulating-free-testosterone","display_name":"Circulating free testosterone concentration","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Eight men per placebo, 3 g and 6 g arm; at least two years of resistance training.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small groups and short duration; calculated free testosterone is not a direct free-hormone assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"D-Aspartate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"d-aspartate","display_name":"D-Aspartate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"More was not better in this short dose-comparison trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Three and six grams supplementation of d-aspartic acid in resistance trained men. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25844073/ · DOI 10.1186/s12970-015-0078-7","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"fcbcae5d-88d3-5245-94b5-e20b2dccb091","evidence_kind":"source_excerpt","locator":"Lines 344-350","start_line":344,"end_line":350,"excerpt":"## d-aspartate-human-dose-trial\nMore was not better in this short dose-comparison trial.\nIn a 24-man resistance-trained trial, 3 g/day for 14 days did not change testosterone; 6 g/day lowered total and calculated free testosterone.\nModel: Eight men per placebo, 3 g and 6 g arm; at least two years of resistance training.\nLimitations: Small groups and short duration; calculated free testosterone is not a direct free-hormone assay.\nEvidence access: Primary full text\nThree and six grams supplementation of d-aspartic acid in resistance trained men. · 2015 · https://pubmed.ncbi.nlm.nih.gov/25844073/ · DOI 10.1186/s12970-015-0078-7","model_system":"Eight men per placebo, 3 g and 6 g arm; at least two years of resistance training.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"3751103e-e256-5615-b24f-39cc76ccfb47","stable_key":"import-9a47f338-d127-5e4d-abf6-e99056833a69","title":"D-Aspartate: synthesis, clearance, neural and endocrine mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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