{"id":"2680b311-d608-5781-83a0-013dee813296","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:epithelial-source","predicate":"reported_relationship","statement":"Thymic epithelial cells produce thymulin; metal-dependent antibody recognition must be distinguished from peptide quantity and biological activity.","claim_class":"mechanistic","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"e3a8cd86-e679-5732-ac3d-cc77c118d02c","mechanism_event_label":"Thymic epithelial cells produce thymulin; metal-dependent antibody recognition must be distinguished from peptide quantity and biological activity.","subject":{"id":"abb81d05-773a-578e-842e-fa332b34615c","slug":"human-thymic-epithelial-cells","display_name":"Human thymic epithelial cells","entity_type_key":"cell_type"},"object":{"id":"23819462-9bdf-5856-beac-68b3dca9cf85","slug":"thymulin","display_name":"Thymulin","entity_type_key":"peptide"},"evidence_count":1,"mechanism_event":{"id":"e3a8cd86-e679-5732-ac3d-cc77c118d02c","stable_key":"18100170-a014-51c3-adeb-9dab4162b8cc:epithelial-source-event","event_type":"biochemical_relationship","label":"Thymic epithelial cells produce thymulin; metal-dependent antibody recognition must be distinguished from peptide quantity and biological activity.","description":"Thymic epithelial cells (TECs) are the established source. Production, secretion and metal-dependent activity should be represented as distinct processes. Antibody recognition of thymulin in TECs and serum also depends on the assay's sensitivity to metal-associated conformation. 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The complete source passage retains qualifications; unspecified doses/timing have not been extracted here. No clinical efficacy, nutrient deficiency or unique molecular mediation is inferred.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Thymic epithelial cells produce thymulin; metal-dependent antibody recognition must be distinguished from peptide quantity and biological activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"A zinc-dependent epitope on the molecule of thymulin, a thymic hormone. | 1985 | DOI 10.1073/pnas.82.20.7035 | PMID 2413455 | https://doi.org/10.1073/pnas.82.20.7035","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 33-33; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"19137f7f-2d6c-5701-b481-8d1fc71250ab","evidence_kind":"source_excerpt","locator":"Lines 33-33","start_line":33,"end_line":33,"excerpt":"Thymic epithelial cells (TECs) are the established source. 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