{"id":"26774fba-2983-5c42-8730-80a891523e32","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-imp-human-metformin","predicate":"associates_with","statement":"Metformin-treated participants with high blood glucose had higher circulating imidazole propionate in the observational comparison.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"2efe0551-d0a9-5a77-b9d0-e4d96a315e6a","mechanism_event_label":"The human association is consistent with a hypothesis but does not test the mechanism.","subject":{"id":"06c093ed-025c-54bc-8016-6a3da64ffbf9","slug":"imidazole-propionate","display_name":"Imidazole propionate","entity_type_key":"small_molecule"},"object":{"id":"607ee198-b69e-5afe-9c5f-25c5fc7ebad8","slug":"human-metformin-poor-glucose-control","display_name":"Poor glucose control among metformin-treated participants","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"2efe0551-d0a9-5a77-b9d0-e4d96a315e6a","stable_key":"911fb3c7-8cc3-5667-b677-5682fab67648:histidine-imp-human-metformin-event","event_type":"observed_relationship","label":"The human association is consistent with a hypothesis but does not test the mechanism.","description":"Metformin-treated participants with high blood glucose had higher circulating imidazole propionate in the observational comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"06c093ed-025c-54bc-8016-6a3da64ffbf9","slug":"imidazole-propionate","display_name":"Imidazole propionate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"607ee198-b69e-5afe-9c5f-25c5fc7ebad8","slug":"human-metformin-poor-glucose-control","display_name":"Poor glucose control among metformin-treated participants","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"44374451-3436-5136-a8ae-5dcc6d8c353b","slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"519971b1-5aef-5ad7-8022-840144855cd0","slug":"metformin","display_name":"Metformin","entity_type_key":"drug"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human type 2 diabetes plasma comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Confounding and reverse causation remain possible; no randomized metabolite or histidine intervention.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Histidine collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"histidine","display_name":"L-Histidine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"The human association is consistent with a hypothesis but does not test the mechanism.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32783890/ · DOI 10.1016/j.cmet.2020.07.012","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"8aa8c086-644f-55fb-bb91-6128d9341e6b","evidence_kind":"source_excerpt","locator":"Lines 354-360","start_line":354,"end_line":360,"excerpt":"## histidine-imp-human-metformin\nThe human association is consistent with a hypothesis but does not test the mechanism.\nMetformin-treated participants with high blood glucose had higher circulating imidazole propionate in the observational comparison.\nModel: Human type 2 diabetes plasma comparison.\nLimitations: Confounding and reverse causation remain possible; no randomized metabolite or histidine intervention.\nEvidence access: Primary full text\nMicrobial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation. · 2020 · https://pubmed.ncbi.nlm.nih.gov/32783890/ · DOI 10.1016/j.cmet.2020.07.012","model_system":"Human type 2 diabetes plasma comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"ce59e6c9-1213-523b-9d0b-400b7a81cd1c","stable_key":"import-911fb3c7-8cc3-5667-b677-5682fab67648","title":"L-Histidine: supply, catabolism, histamine, receptors and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"cb672530ec8b4a4542d0f3957e80ca76bb0449e9f988845b0f7681f623c4ec9b","revision_id":"19a7f26c-d9a1-5411-a81d-025f3d98a452","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}