{"id":"26559ac5-0010-5eb9-931c-4091c4a9ba3d","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-bile-vitamin-absorption","predicate":"failure_causes","statement":"The pediatric bile acid amidation disorder was associated with insufficient effective duodenal bile acids, fat-soluble vitamin deficiency and growth failure in affected children.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9aaa95b5-82a6-589e-831e-d007c0cdc9a5","mechanism_event_label":"Failed bile chemistry can make fat-soluble nutrient absorption fail downstream.","subject":{"id":"e3b41128-9aa7-55b5-9f14-25c8bf145ba4","slug":"human-bile-amidation","display_name":"Human hepatic bile acid amidation","entity_type_key":"cellular_process"},"object":{"id":"516324e2-fb35-50d3-8400-72ab9cc78b8d","slug":"human-bile-defect-vitamin-malabsorption","display_name":"Fat-soluble vitamin malabsorption in human bile acid amidation deficiency","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9aaa95b5-82a6-589e-831e-d007c0cdc9a5","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-bile-vitamin-absorption-event","event_type":"observed_relationship","label":"Failed bile chemistry can make fat-soluble nutrient absorption fail downstream.","description":"The pediatric bile acid amidation disorder was associated with insufficient effective duodenal bile acids, fat-soluble vitamin deficiency and growth failure in affected children.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e3b41128-9aa7-55b5-9f14-25c8bf145ba4","slug":"human-bile-amidation","display_name":"Human hepatic bile acid amidation","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"516324e2-fb35-50d3-8400-72ab9cc78b8d","slug":"human-bile-defect-vitamin-malabsorption","display_name":"Fat-soluble vitamin malabsorption in human bile acid amidation deficiency","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"b1127d16-82be-5dd0-90db-aa1af23011f0","slug":"baat","display_name":"Human bile acid-CoA:amino acid N-acyltransferase / BAAT","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"4f4ae3d8-b415-53b7-8262-46d90815a0c9","slug":"taurocholate","display_name":"Taurocholate","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human genetic disease cohort and biochemical characterization.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The study tests conjugation failure, not taurine supplement efficacy or one universal vitamin deficit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Failed bile chemistry can make fat-soluble nutrient absorption fail downstream.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23415802/ · DOI 10.1053/j.gastro.2013.02.004","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"36e220ba-7f0f-5149-889b-5eeac28fdffe","evidence_kind":"source_excerpt","locator":"Lines 321-327","start_line":321,"end_line":327,"excerpt":"## taurine-bile-vitamin-absorption\nFailed bile chemistry can make fat-soluble nutrient absorption fail downstream.\nThe pediatric bile acid amidation disorder was associated with insufficient effective duodenal bile acids, fat-soluble vitamin deficiency and growth failure in affected children.\nModel: Human genetic disease cohort and biochemical characterization.\nLimitations: The study tests conjugation failure, not taurine supplement efficacy or one universal vitamin deficit.\nEvidence access: Primary abstract\nGenetic defects in bile acid conjugation cause fat-soluble vitamin deficiency. · 2013 · https://pubmed.ncbi.nlm.nih.gov/23415802/ · DOI 10.1053/j.gastro.2013.02.004","model_system":"Human genetic disease cohort and biochemical characterization.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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