{"id":"2612e3e2-87cb-58ff-b19e-b047b64fb86f","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:scope-aged-garlic-wlosinska-2020","predicate":"has_distinct_clinical_preparation_comparison","statement":"The aged-garlic-wlosinska-2020 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"d2837fe1-215f-5697-a72e-eedb11fd42d1","mechanism_event_label":"The aged-garlic-wlosinska-2020 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","subject":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"object":{"id":"d7670c3d-c275-5413-895a-53b1b7567ddd","slug":"aged-garlic-wlosinska-2020","display_name":"Aged garlic extract in the European 2020 coronary-calcium trial","entity_type_key":"botanical"},"evidence_count":1,"mechanism_event":{"id":"d2837fe1-215f-5697-a72e-eedb11fd42d1","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:scope-aged-garlic-wlosinska-2020-event","event_type":"experimental_scope_comparison","label":"The aged-garlic-wlosinska-2020 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","description":"**Coronary imaging.** A European trial randomized 104 participants to 2.4 g/day aged garlic extract or placebo for one year; ninety-three were analyzed. It reported lower coronary-calcium progression with the extract. It was retrospectively registered and received manufacturer funding and product support alongside other funding. Coronary calcium progression is an imaging outcome, not proof of plaque reversal, fewer infarctions, or allicin target engagement. It must remain distinct from low-attenuation plaque and total plaque-volume measurements. [Wlosinska 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7191741/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"85c86fcf-3060-5fae-b567-4f089990ab2d","slug":"allicin","display_name":"Allicin","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"d7670c3d-c275-5413-895a-53b1b7567ddd","slug":"aged-garlic-wlosinska-2020","display_name":"Aged garlic extract in the European 2020 coronary-calcium trial","entity_type_key":"botanical"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text available; selected claim-relevant methods, results, tables/figures and limitations reviewed. Supplemental proteome and all secondary findings are not exhaustively extracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Editorial study-scope relationship, not experimental causation or chemical composition.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Unsigned navigation only. Does not assert allicin content, metabolic conversion, causation or intervention equivalence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The aged-garlic-wlosinska-2020 study is a preparation-specific translation comparison; its outcomes are not assigned to purified allicin. ","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of aged garlic extract on the atherosclerotic process - a randomized double-blind placebo-controlled trial. | 2020 | DOI 10.1186/s12906-020-02932-5 | PMID 32349742 | https://pubmed.ncbi.nlm.nih.gov/32349742/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC7191741/ | https://doi.org/10.1186/s12906-020-02932-5","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 93-93; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f7b747df-3342-543f-8519-ccd50ff1339c","evidence_kind":"source_excerpt","locator":"Lines 93-93","start_line":93,"end_line":93,"excerpt":"**Coronary imaging.** A European trial randomized 104 participants to 2.4 g/day aged garlic extract or placebo for one year; ninety-three were analyzed. It reported lower coronary-calcium progression with the extract. It was retrospectively registered and received manufacturer funding and product support alongside other funding. Coronary calcium progression is an imaging outcome, not proof of plaque reversal, fewer infarctions, or allicin target engagement. It must remain distinct from low-attenuation plaque and total plaque-volume measurements. [Wlosinska 2020](https://pmc.ncbi.nlm.nih.gov/articles/PMC7191741/)","model_system":"Editorial study-scope relationship, not experimental causation or chemical composition.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"10820a6b-594a-547d-97f9-906ab4cc1d6e","stable_key":"import-c836a883-ac18-5eb2-9971-2f0b542feba8","title":"Allicin: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"2475d3eb681100a0a34577a47b7cba5b251df866fbd6ce795122ccabee360018","revision_id":"590df96d-2ed1-5763-b04c-bf0e096e603c","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}