{"id":"260adc07-712a-5cad-b212-2a773cbd8a2f","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-rat-inflammation-liver-muscle","predicate":"reduced_rat_hepatic_plp","statement":"Pair-fed rats with adjuvant arthritis had lower plasma and liver PLP at peak/chronic inflammation, while muscle PLP and urinary 4-pyridoxic acid were not significantly changed.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"9adce81a-8f3f-5369-badb-eb9702ce1732","mechanism_event_label":"In this animal experiment, inflammation changed some B6 pools more than others despite matched food supply.","subject":{"id":"1fc8af78-46e8-5579-a95b-cc5f8318b18a","slug":"acute-inflammation","display_name":"Acute inflammation","entity_type_key":"cellular_process"},"object":{"id":"c7e1adf1-e85c-5e3f-a3bb-599484937d0f","slug":"hepatic-plp-concentration","display_name":"Hepatic pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9adce81a-8f3f-5369-badb-eb9702ce1732","stable_key":"1310afbd-6010-586e-805d-551d846da421:b6-rat-inflammation-liver-muscle-event","event_type":"observed_intervention","label":"In this animal experiment, inflammation changed some B6 pools more than others despite matched food supply.","description":"Pair-fed rats with adjuvant arthritis had lower plasma and liver PLP at peak/chronic inflammation, while muscle PLP and urinary 4-pyridoxic acid were not significantly changed.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8de675d4-45d9-505d-9a5d-54f60f2afc53","slug":"muscle-plp-concentration","display_name":"Muscle pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"role":"contrasting_pool","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6b656ff5-9532-5da4-8eea-8ca163a48649","slug":"pyridoxal-phosphate","display_name":"PLP","entity_type_key":"small_molecule"},"role":"measured_vitamer","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"1fc8af78-46e8-5579-a95b-cc5f8318b18a","slug":"acute-inflammation","display_name":"Acute inflammation","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c7e1adf1-e85c-5e3f-a3bb-599484937d0f","slug":"hepatic-plp-concentration","display_name":"Hepatic pyridoxal 5-prime-phosphate concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"experimental_model","value_text":"Human cross-sectional comparison: 33 RA patients, 17 healthy controls; separate pair-fed rat adjuvant-arthritis experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Human observational samples; rats studied at peak day 21 and chronic day 42 inflammation. Human arm shares recruitment program with supplementation study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Separate rat model; neither universal muscle preservation nor directly measured human liver deficiency.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-b6","display_name":"Vitamin B6","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Rattus norvegicus","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"In this animal experiment, inflammation changed some B6 pools more than others despite matched food supply.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b6-chiang2005-inflammation] Inflammation causes tissue-specific depletion of vitamin B6 (2005). https://pubmed.ncbi.nlm.nih.gov/16277678/ DOI: 10.1186/ar1821","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Rat liver, skeletal muscle, plasma and urine","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"trigger_kind","value_text":"biomarker_context","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null}],"evidence":[{"id":"3f9202c1-68a3-5b09-8459-6b6eee1b9432","evidence_kind":"source_excerpt","locator":"Lines 1535-1545","start_line":1535,"end_line":1545,"excerpt":"### b6-rat-inflammation-liver-muscle\nPair-fed rats with adjuvant arthritis had lower plasma and liver PLP at peak/chronic inflammation, while muscle PLP and urinary 4-pyridoxic acid were not significantly changed.\nCondition category: biomarker_context\nnutrient_topic: Vitamin B6 research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: In this animal experiment, inflammation changed some B6 pools more than others despite matched food supply.\norganism: Rattus norvegicus\ntissue_or_cell_type: Rat liver, skeletal muscle, plasma and urine\nexperimental_model: Human cross-sectional comparison: 33 RA patients, 17 healthy controls; separate pair-fed rat adjuvant-arthritis experiment.\nlimitations: Separate rat model; neither universal muscle preservation nor directly measured human liver deficiency.\nexposure: Human observational samples; rats studied at peak day 21 and chronic day 42 inflammation. Human arm shares recruitment program with supplementation study.\n[b6-chiang2005-inflammation] Inflammation causes tissue-specific depletion of vitamin B6 (2005). https://pubmed.ncbi.nlm.nih.gov/16277678/ DOI: 10.1186/ar1821","model_system":"Human cross-sectional comparison: 33 RA patients, 17 healthy controls; separate pair-fed rat adjuvant-arthritis experiment.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b6-chiang2005-inflammation] Inflammation causes tissue-specific depletion of vitamin B6 (2005). https://pubmed.ncbi.nlm.nih.gov/16277678/ DOI: 10.1186/ar1821","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"251773bb-16f5-5903-b135-db4a61d9dec4","stable_key":"import-1310afbd-6010-586e-805d-551d846da421","title":"Vitamin B6: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ef0019b344b2219220f801a84d0d138ff6880c1be1a59540d9034bfa4334f61e","revision_id":"cac3555f-48af-5c52-a84e-add4482c87fb","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}