{"id":"25f94925-ce72-56fd-b081-369b171824fc","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-nonacylated-comparison","predicate":"had_similar_dose_normalized_exposure_to","statement":"Exposure normalized to molar dose was similar to delphinidin 3-glucoside.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"31f7bcd9-1c1a-5b81-a380-f091e2abf3bd","mechanism_event_label":"Large molecular decoration did not eliminate uptake in this rat experiment.","subject":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"object":{"id":"5a3646a9-d8c9-5925-b6a8-beebe930333c","slug":"delphinidin-3-glucoside","display_name":"Delphinidin 3-O-beta-D-glucopyranoside","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"31f7bcd9-1c1a-5b81-a380-f091e2abf3bd","stable_key":"e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff:nasunin-nonacylated-comparison-event","event_type":"observed_intervention","label":"Large molecular decoration did not eliminate uptake in this rat experiment.","description":"Exposure normalized to molar dose was similar to delphinidin 3-glucoside.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6553997f-f098-5507-95b4-0fdb8aac491d","slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5a3646a9-d8c9-5925-b6a8-beebe930333c","slug":"delphinidin-3-glucoside","display_name":"Delphinidin 3-O-beta-D-glucopyranoside","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/nasunin-research/16848510.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a\", \"start_char\": 0, \"end_char\": 1308, \"text_sha256\": \"72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Oral isomer pharmacokinetics with chromatographic metabolite analysis","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oral purified cis/trans nasunin; plasma follow-up to 8 h","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Dose-normalized Cmax/AUC comparison is not absolute oral bioavailability. Nondetection applies to the tested analytes, method and window; no human or blood-brain-barrier conclusion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Nasunin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"nasunin","display_name":"Nasunin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rats","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Large molecular decoration did not eliminate uptake in this rat experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Plasma and urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"119c0ec5-2db4-5963-a5a8-6b833580fb22","evidence_kind":"source_excerpt","locator":"Lines 757-768","start_line":757,"end_line":768,"excerpt":"### nasunin-nonacylated-comparison\nExposure normalized to molar dose was similar to delphinidin 3-glucoside.\nCondition category: normal\nnutrient_topic: Nasunin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Large molecular decoration did not eliminate uptake in this rat experiment.\norganism: Rats\ntissue_or_cell_type: Plasma and urine\nexperimental_model: Oral isomer pharmacokinetics with chromatographic metabolite analysis\nlimitations: Dose-normalized Cmax/AUC comparison is not absolute oral bioavailability. Nondetection applies to the tested analytes, method and window; no human or blood-brain-barrier conclusion.\nexposure: Oral purified cis/trans nasunin; plasma follow-up to 8 h\nevidence_span: {\"source_cache\": \"artifacts/nasunin-research/16848510.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a\", \"start_char\": 0, \"end_char\": 1308, \"text_sha256\": \"72244518913802f8f2018e3e6e7add9914294e49c58b9e9733c26a550e86479a\"}\n[nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s","model_system":"Oral isomer pharmacokinetics with chromatographic metabolite analysis","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [nasunin-p16848510] Gastrointestinal uptake of nasunin, acylated anthocyanin in eggplant. (2006). https://pubmed.ncbi.nlm.nih.gov/16848510/ DOI: 10.1021/jf060238s","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"2c43df19-ccb0-58f1-b9a4-bc92cda6de5a","stable_key":"import-e1af6d55-ced5-56c9-9a2d-8cc2ae6ec3ff","title":"Nasunin: identity, redox chemistry and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"56552c208433294bf9a6c95513d981dbe4d00fd8336c121816d7b8bd6604d50e","revision_id":"b0296d49-32d7-52dc-a23c-5e862da0fba3","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}