{"id":"25b9be4f-beaf-5980-8688-3b03a720f70e","stable_key":"c3df3634-4c3a-5099-a5d9-e4f6344c1084:aass-saccharopine-dehydrogenase","predicate":"converted_to","statement":"The AASS dehydrogenase domain oxidatively cleaves saccharopine, producing alpha-aminoadipate semialdehyde and glutamate with NAD+ reduction.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"7d31de73-d10c-55d0-bd49-07329da82d4d","mechanism_event_label":"The second AASS activity opens the next lysine breakdown step.","subject":{"id":"d70bb0d3-bb08-5b47-9ac0-5c7d8b56dd24","slug":"saccharopine","display_name":"Saccharopine","entity_type_key":"small_molecule"},"object":{"id":"7d67a576-2d6f-5556-863c-d1dfd273f687","slug":"alpha-aminoadipate-semialdehyde","display_name":"alpha-Aminoadipate 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reduction.\nPlain language: The second AASS activity opens the next lysine breakdown step.\nCondition category: normal\norganism: Homo sapiens\ntissue_or_cell_type: Mitochondrial matrix\nexperimental_model: Human AASS cloning, localization and familial hyperlysinemia genetics\nlimitations: Biochemical capacity does not quantify flux in every human tissue.\n[sacksteder2000] Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia (2000). https://pmc.ncbi.nlm.nih.gov/articles/PMC1378037/ DOI: 10.1086/302919","model_system":"Human AASS cloning, localization and familial hyperlysinemia genetics","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact quote from the accompanying curation document, not from publisher text. Original study references: [sacksteder2000] Identification of the alpha-aminoadipic semialdehyde synthase gene, which is defective in familial hyperlysinemia (2000). https://pmc.ncbi.nlm.nih.gov/articles/PMC1378037/ DOI: 10.1086/302919","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"7633bde7-dcc9-5086-91c6-a45eb96857f3","stable_key":"import-c3df3634-4c3a-5099-a5d9-e4f6344c1084","title":"L-Lysine: mechanism-first literature curation (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"93998d47c21525409ba82f1c82ededf2893dff15fbe61c7deffc175b0e298e97","revision_id":"3897e31f-6624-59e1-a053-8a81b7361632","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}