{"id":"25b642e1-8711-5e7a-b26b-b33c5ebd7e33","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-lowers-macrophage-ros","predicate":"reduces","statement":"(+)-Lariciresinol inhibited reactive oxygen species generation in murine macrophages in a dose-dependent manner without cytotoxicity.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"37ded252-4568-5253-b443-3cf6e1952da0","mechanism_event_label":"(+)-Lariciresinol inhibited reactive oxygen species generation in murine macrophages in a dose-dependent manner without cytotoxicity.","subject":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"object":{"id":"ba791e1e-c1db-5a6a-aea2-b7a44e8d944a","slug":"raw2647-reactive-oxygen-generation","display_name":"Reactive oxygen species generation in RAW 264.7 macrophages","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"37ded252-4568-5253-b443-3cf6e1952da0","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-lowers-macrophage-ros-event","event_type":"observed_relationship","label":"(+)-Lariciresinol inhibited reactive oxygen species generation in murine macrophages in a dose-dependent manner without cytotoxicity.","description":"(+)-Lariciresinol inhibited reactive oxygen species generation in murine macrophages in a dose-dependent manner without cytotoxicity.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ba791e1e-c1db-5a6a-aea2-b7a44e8d944a","slug":"raw2647-reactive-oxygen-generation","display_name":"Reactive oxygen species generation in RAW 264.7 macrophages","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"(+)-Lariciresinol, dose-dependent","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The abstract does not state the stimulus concentration or the active range.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"(+)-Lariciresinol inhibited reactive oxygen species generation in murine macrophages in a dose-dependent manner without cytotoxicity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38. 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(2017). https://pubmed.ncbi.nlm.nih.gov/28378774/ DOI: 10.1038/srep46035\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"48c58761-0291-5bad-a926-75e904b2d802","stable_key":"import-96d9034a-2550-5f3c-b767-1767c982533c","title":"Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. 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