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It sits alongside, not instead of, the redox explanation for fatty liver.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Alcohol rewires the liver’s fat-building programme through the energy sensor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p21953514] Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice. (2012). https://pubmed.ncbi.nlm.nih.gov/21953514/ DOI: 10.1002/hep.24708","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Liver","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0fbbc08a-55d3-561a-ab8e-9956eab68952","evidence_kind":"source_excerpt","locator":"Lines 436-447","start_line":436,"end_line":447,"excerpt":"### alcohol-lipin1-srebp\nEthanol regulated hepatic lipin-1 through AMP-activated protein kinase and sterol regulatory element-binding protein 1 signalling in mice.\nCondition category: normal\nnutrient_topic: Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.\nplain_language: Alcohol rewires the liver’s fat-building programme through the energy sensor.\norganism: Mouse\ntissue_or_cell_type: Liver\nexperimental_model: Ethanol-fed mice with hepatic AMPK and SREBP-1 measurement\nlimitations: A signalling route to steatosis measured in mice. It sits alongside, not instead of, the redox explanation for fatty liver.\nexposure: Chronic ethanol feeding\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/21953514.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"acfcd2656e45aab9abcf367ed27e447001ddaa55ac143e9cc2f24b0958ea15a7\", \"start_char\": 0, \"end_char\": 1626, \"text_sha256\": \"acfcd2656e45aab9abcf367ed27e447001ddaa55ac143e9cc2f24b0958ea15a7\"}\n[alcohol-p21953514] Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice. (2012). https://pubmed.ncbi.nlm.nih.gov/21953514/ DOI: 10.1002/hep.24708","model_system":"Ethanol-fed mice with hepatic AMPK and SREBP-1 measurement","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [alcohol-p21953514] Regulation of hepatic lipin-1 by ethanol: role of AMP-activated protein kinase/sterol regulatory element-binding protein 1 signaling in mice. (2012). https://pubmed.ncbi.nlm.nih.gov/21953514/ DOI: 10.1002/hep.24708","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4b310db0-1387-548c-9e3d-6d2ed634b2cd","stable_key":"import-fcc4fa9c-4dc8-5566-b780-1a486c4d3e72","title":"Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"cb7e8dc390e8bf302cd5e230cadff6ce9847b4aad8a3691a308964d93ba59a85","revision_id":"4b344e1e-4129-579c-a058-50262b03f9a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}