{"id":"259ed3e5-c04b-5f3d-a7b3-4b9334bb6849","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-mglur-mobilisation","predicate":"increases","statement":"Diacylglycerol lipase-alpha has a key role in metabotropic glutamate receptor-dependent endocannabinoid mobilisation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"9d0fa3c4-4e48-5352-99d2-5332a7ad913b","mechanism_event_label":"Glutamate signalling is one of the triggers that tells the cell to make the messenger.","subject":{"id":"ba4eb48f-7dbd-504d-8f14-3c6b2fa078de","slug":"mglur-signalling","display_name":"Metabotropic glutamate receptor signalling","entity_type_key":"cellular_process"},"object":{"id":"e0aeb1b3-fbfb-5ac4-a29c-d5171072c256","slug":"2-arachidonoylglycerol","display_name":"2-Arachidonoylglycerol / 2-AG","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"9d0fa3c4-4e48-5352-99d2-5332a7ad913b","stable_key":"05a3cf47-e660-5ab3-8c32-5eba9847cf0a:thc-mglur-mobilisation-event","event_type":"biochemical_relationship","label":"Glutamate signalling is one of the triggers that tells the cell to make the messenger.","description":"Diacylglycerol lipase-alpha has a key role in metabotropic glutamate receptor-dependent endocannabinoid mobilisation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"db61034c-b170-5491-acb0-c955ce2e2251","slug":"dagla","display_name":"Diacylglycerol lipase alpha / DAGLA","entity_type_key":"protein"},"role":"producing_enzyme","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ba4eb48f-7dbd-504d-8f14-3c6b2fa078de","slug":"mglur-signalling","display_name":"Metabotropic glutamate receptor signalling","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e0aeb1b3-fbfb-5ac4-a29c-d5171072c256","slug":"2-arachidonoylglycerol","display_name":"2-Arachidonoylglycerol / 2-AG","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/thc-research/17584991.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5d27e66f2883f2d105cb492c1a5acd7a1aa7a27b81577ddd3759ee252622d0ac\", \"start_char\": 0, \"end_char\": 1860, \"text_sha256\": \"5d27e66f2883f2d105cb492c1a5acd7a1aa7a27b81577ddd3759ee252622d0ac\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Pharmacological and genetic dissection of mGluR-dependent endocannabinoid mobilisation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Metabotropic glutamate receptor stimulation with DAGLα inhibition","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Links the messenger production to a specific upstream receptor, which is what makes the system demand-driven.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.","comparator":null,"unit":null,"notes":"","entity":{"slug":"tetrahydrocannabinol","display_name":"Delta-9-tetrahydrocannabinol / THC","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Rodent","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Glutamate signalling is one of the triggers that tells the cell to make the messenger.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[thc-p17584991] A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. (2007). https://pubmed.ncbi.nlm.nih.gov/17584991/ DOI: 10.1124/mol.107.037796","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brain slices","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a1f1f6ef-432e-5528-a061-e662957380d0","evidence_kind":"source_excerpt","locator":"Lines 348-359","start_line":348,"end_line":359,"excerpt":"### thc-mglur-mobilisation\nDiacylglycerol lipase-alpha has a key role in metabotropic glutamate receptor-dependent endocannabinoid mobilisation.\nCondition category: normal\nnutrient_topic: THC research collection; topical membership is not evidence of a direct clinical effect, and THC is recorded separately from the endocannabinoids it imitates.\nplain_language: Glutamate signalling is one of the triggers that tells the cell to make the messenger.\norganism: Rodent\ntissue_or_cell_type: Brain slices\nexperimental_model: Pharmacological and genetic dissection of mGluR-dependent endocannabinoid mobilisation\nlimitations: Links the messenger production to a specific upstream receptor, which is what makes the system demand-driven.\nexposure: Metabotropic glutamate receptor stimulation with DAGLα inhibition\nevidence_span: {\"source_cache\": \"artifacts/thc-research/17584991.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"5d27e66f2883f2d105cb492c1a5acd7a1aa7a27b81577ddd3759ee252622d0ac\", \"start_char\": 0, \"end_char\": 1860, \"text_sha256\": \"5d27e66f2883f2d105cb492c1a5acd7a1aa7a27b81577ddd3759ee252622d0ac\"}\n[thc-p17584991] A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. (2007). https://pubmed.ncbi.nlm.nih.gov/17584991/ DOI: 10.1124/mol.107.037796","model_system":"Pharmacological and genetic dissection of mGluR-dependent endocannabinoid mobilisation","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [thc-p17584991] A key role for diacylglycerol lipase-alpha in metabotropic glutamate receptor-dependent endocannabinoid mobilization. (2007). https://pubmed.ncbi.nlm.nih.gov/17584991/ DOI: 10.1124/mol.107.037796","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b4367320-9724-507a-bead-6932fa0a78cb","stable_key":"import-05a3cf47-e660-5ab3-8c32-5eba9847cf0a","title":"THC: the cannabinoid receptors, the endocannabinoid system it occupies, what the drug does, and the dietary fat it is built from (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"60abc81737d18b7a50b01ca487e38291774ee15d9777651aa2d3eac8670ac3b2","revision_id":"2cba3552-af89-580d-b20a-8cfb1b14f9e7","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}