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(2019). https://pubmed.ncbi.nlm.nih.gov/30742493/ DOI: 10.1165/rcmb.2018-0158oc","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ciliated airway surface","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"903aee8b-d101-5b35-a2f9-9404fcb1420d","evidence_kind":"source_excerpt","locator":"Lines 1056-1067","start_line":1056,"end_line":1067,"excerpt":"### chloride-surface-pendrin\nIL-4-induced pendrin supported chloride/bicarbonate exchange in primary airway surface cultures.\nCondition category: normal\nnutrient_topic: Chloride research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Different airway cells can use a different balance of the same transport proteins.\norganism: Human nasal and bronchial epithelia\ntissue_or_cell_type: Ciliated airway surface\nexperimental_model: Primary epithelial cultures and native tissue\nlimitations: Inflamed surface epithelium differs from Calu-3; no universal airway assignment.\nexposure: IL-4 induction and pendrin knockdown\nevidence_span: {\"source_cache\": \"artifacts/chloride-research/30742493.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"1ff038684ceacd46ad1e237d0cf13337924ec0f611d00a373cd3cbeeeb31864a\", \"start_char\": 0, \"end_char\": 1882, \"text_sha256\": \"1ff038684ceacd46ad1e237d0cf13337924ec0f611d00a373cd3cbeeeb31864a\"}\n[chloride-p30742493] Pendrin Mediates Bicarbonate Secretion and Enhances Cystic Fibrosis Transmembrane Conductance Regulator Function in Airway Surface Epithelia. 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