{"id":"2578fe12-ee98-56b9-b9c3-903c79d0df4c","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-xanthin-redox-null","predicate":"no_detected_effect","statement":"XANTHIN found no significant treatment effect on its oxidative-stress and inflammatory endpoints, including F2-isoprostanes and pentraxin-3.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"46f72681-4c9e-50cc-b4df-02c5fbb4fb0a","mechanism_event_label":"Measured antioxidant and inflammatory outcomes were also null.","subject":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"object":{"id":"ea44d394-27b3-50bf-8002-3fc1014b94ec","slug":"human-astaxanthin-oxidative-markers","display_name":"Human oxidative-stress biomarker response to astaxanthin","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"46f72681-4c9e-50cc-b4df-02c5fbb4fb0a","stable_key":"a8bedee0-a740-5bbb-921e-bfd144c7b68c:astaxanthin-xanthin-redox-null-event","event_type":"observed_relationship","label":"Measured antioxidant and inflammatory outcomes were also null.","description":"XANTHIN found no significant treatment effect on its oxidative-stress and inflammatory endpoints, including F2-isoprostanes and pentraxin-3.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"1bf8b9c0-9c38-5c8a-b5da-f00b0eeca36f","slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ea44d394-27b3-50bf-8002-3fc1014b94ec","slug":"human-astaxanthin-oxidative-markers","display_name":"Human oxidative-stress biomarker response to astaxanthin","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same one-year renal-transplant trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a separate replication from the arterial-stiffness analysis; absence of detection does not prove zero effect in all populations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Astaxanthin collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"astaxanthin","display_name":"Astaxanthin","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Measured antioxidant and inflammatory outcomes were also null.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Astaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial). · 2016 · https://pubmed.ncbi.nlm.nih.gov/26675778/ · DOI 10.3945/ajcn.115.115477","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e0ba2735-9a24-59be-9239-d40cd3275a00","evidence_kind":"source_excerpt","locator":"Lines 438-444","start_line":438,"end_line":444,"excerpt":"## astaxanthin-xanthin-redox-null\nMeasured antioxidant and inflammatory outcomes were also null.\nXANTHIN found no significant treatment effect on its oxidative-stress and inflammatory endpoints, including F2-isoprostanes and pentraxin-3.\nModel: Same one-year renal-transplant trial.\nLimitations: Not a separate replication from the arterial-stiffness analysis; absence of detection does not prove zero effect in all populations.\nEvidence access: Primary abstract\nAstaxanthin has no effect on arterial stiffness, oxidative stress, or inflammation in renal transplant recipients: a randomized controlled trial (the XANTHIN trial). · 2016 · https://pubmed.ncbi.nlm.nih.gov/26675778/ · DOI 10.3945/ajcn.115.115477","model_system":"Same one-year renal-transplant trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4fd91ea6-78b4-5bfe-93e3-686fbef9f678","stable_key":"import-a8bedee0-a740-5bbb-921e-bfd144c7b68c","title":"Astaxanthin: transport, membrane chemistry, signaling and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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