{"id":"2570a348-2963-5ab9-a2c3-01156fa8d64a","stable_key":"08ce9896-9d1c-5bbf-b705-5bfe771091d5:b7-hair-biotin-alone","predicate":"did_not_significantly_change","statement":"In the 10-man crossover study, biotin alone changed mean hair growth from 2.50 to 2.47 mm/week (P=0.53) over 14 days.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"7c804b29-6b56-5ae2-b262-b4860e08f94a","mechanism_event_label":"Biotin alone did not speed hair growth in this small short experiment.","subject":{"id":"37a8e96b-f95b-5ba7-a0bc-8ed3cfaf5fd8","slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"},"object":{"id":"64cfe2ce-5fc4-514a-9a79-370789d0cfe9","slug":"healthy-male-hair-growth-rate","display_name":"Occipital hair growth rate in healthy men","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"7c804b29-6b56-5ae2-b262-b4860e08f94a","stable_key":"08ce9896-9d1c-5bbf-b705-5bfe771091d5:b7-hair-biotin-alone-event","event_type":"observed_intervention","label":"Biotin alone did not speed hair growth in this small short experiment.","description":"In the 10-man crossover study, biotin alone changed mean hair growth from 2.50 to 2.47 mm/week (P=0.53) over 14 days.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"37a8e96b-f95b-5ba7-a0bc-8ed3cfaf5fd8","slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"64cfe2ce-5fc4-514a-9a79-370789d0cfe9","slug":"healthy-male-hair-growth-rate","display_name":"Occipital hair growth rate in healthy men","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/biotin-research/38688776.fulltext.txt\", \"locator\": \"Exact primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3f46962f37ad560b79a91a05d587ca0be1e5d52089a581d8920771d84b884d2c\", \"start_char\": 4627, \"end_char\": 5539, \"text_sha256\": \"3ead95bf33780d055dc9d137b66ac1359683d0c8e1adc16e58c14d598ea42625\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized-order open crossover study in 10 healthy men without hair disorders","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"14-day courses: oral biotin 5 mg/day, topical minoxidil 5%, or combination; 14-day washouts","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small, short, open study without placebo. Within-period significance in the combination does not establish a biochemical synergy or a treatment for alopecia.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Biotin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"biotin","display_name":"Biotin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Biotin alone did not speed hair growth in this small short experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[b7-p38688776] Efficacy of 5% topical minoxidil versus 5 mg oral biotin versus topical minoxidil and oral biotin on hair growth in men: randomized, crossover, clinical trial. (2024). https://pubmed.ncbi.nlm.nih.gov/38688776/ DOI: 10.1016/j.abd.2023.07.008","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Occipital hair growth","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a3e80e7b-3b74-570b-8384-82f122c645b6","evidence_kind":"source_excerpt","locator":"Lines 1300-1311","start_line":1300,"end_line":1311,"excerpt":"### b7-hair-biotin-alone\nIn the 10-man crossover study, biotin alone changed mean hair growth from 2.50 to 2.47 mm/week (P=0.53) over 14 days.\nCondition category: normal\nnutrient_topic: Biotin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Biotin alone did not speed hair growth in this small short experiment.\norganism: Homo sapiens\ntissue_or_cell_type: Occipital hair growth\nexperimental_model: Randomized-order open crossover study in 10 healthy men without hair disorders\nlimitations: Small, short, open study without placebo. Within-period significance in the combination does not establish a biochemical synergy or a treatment for alopecia.\nexposure: 14-day courses: oral biotin 5 mg/day, topical minoxidil 5%, or combination; 14-day washouts\nevidence_span: {\"source_cache\": \"artifacts/biotin-research/38688776.fulltext.txt\", \"locator\": \"Exact primary full-text span; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"3f46962f37ad560b79a91a05d587ca0be1e5d52089a581d8920771d84b884d2c\", \"start_char\": 4627, \"end_char\": 5539, \"text_sha256\": \"3ead95bf33780d055dc9d137b66ac1359683d0c8e1adc16e58c14d598ea42625\"}\n[b7-p38688776] Efficacy of 5% topical minoxidil versus 5 mg oral biotin versus topical minoxidil and oral biotin on hair growth in men: randomized, crossover, clinical trial. (2024). https://pubmed.ncbi.nlm.nih.gov/38688776/ DOI: 10.1016/j.abd.2023.07.008","model_system":"Randomized-order open crossover study in 10 healthy men without hair disorders","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [b7-p38688776] Efficacy of 5% topical minoxidil versus 5 mg oral biotin versus topical minoxidil and oral biotin on hair growth in men: randomized, crossover, clinical trial. 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