{"id":"256e8a43-743b-504d-80e2-830d2c0e2185","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-rat-regional-distribution","predicate":"has_regional_distribution","statement":"After oral indicaxanthin, pigment was detected in rat cortex, hippocampus, diencephalon, brainstem and cerebellum, but not the striato-pallidal complex.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"39830d27-062a-5218-8939-7552873510db","mechanism_event_label":"After oral indicaxanthin, pigment was detected in rat cortex, hippocampus, diencephalon, brainstem and cerebellum, but not the striato-pallidal complex.","subject":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"object":{"id":"016ae9af-dee6-59fe-bc5d-92583c6314ff","slug":"rat-brain-indicaxanthin-exposure","display_name":"Indicaxanthin exposure in rat brain","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"39830d27-062a-5218-8939-7552873510db","stable_key":"c94a9824-35fb-523c-b421-dc7341218dcb:indicaxanthin-rat-regional-distribution-event","event_type":"observed_relationship","label":"After oral indicaxanthin, pigment was detected in rat cortex, hippocampus, diencephalon, brainstem and cerebellum, but not the striato-pallidal complex.","description":"After oral indicaxanthin, pigment was detected in rat cortex, hippocampus, diencephalon, brainstem and cerebellum, but not the striato-pallidal complex.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f2a6e469-05f0-5596-9054-da926389f584","slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"016ae9af-dee6-59fe-bc5d-92583c6314ff","slug":"rat-brain-indicaxanthin-exposure","display_name":"Indicaxanthin exposure in rat brain","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Indicaxanthin 2 micromol/kg","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Tissue sampling 1 h after dosing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract; 2018 regional neuronal results additionally inspected in PMC full text.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Rats given purified indicaxanthin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Measured regional distribution must not be conflated with local-injection electrophysiology; human brain exposure is unproven.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Dedicated indicaxanthin chapter; original betalain family identity and shared claims preserved.","comparator":null,"unit":null,"notes":"","entity":{"slug":"indicaxanthin","display_name":"Indicaxanthin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Rats given purified indicaxanthin","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"After oral indicaxanthin, pigment was detected in rat cortex, hippocampus, diencephalon, brainstem and cerebellum, but not the striato-pallidal complex.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Brain Distribution and Modulation of Neuronal Excitability by Indicaxanthin From Opuntia Ficus Indica Administered at Nutritionally-Relevant Amounts. (2018). https://pubmed.ncbi.nlm.nih.gov/29867444/ DOI: 10.3389/fnagi.2018.00133","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"Oral administration","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Regional brain tissue","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ae393d1c-71bd-529a-a018-4954f03dbf54","evidence_kind":"source_excerpt","locator":"Lines 228-237","start_line":228,"end_line":237,"excerpt":"## indicaxanthin-rat-regional-distribution\nAfter oral indicaxanthin, pigment was detected in rat cortex, hippocampus, diencephalon, brainstem and cerebellum, but not the striato-pallidal complex.\nModel/species: Rats given purified indicaxanthin\nTissue: Regional brain tissue\nExposure: Indicaxanthin 2 micromol/kg\nRoute: Oral administration\nDuration: Tissue sampling 1 h after dosing\nLimits: Measured regional distribution must not be conflated with local-injection electrophysiology; human brain exposure is unproven.\nPrimary reference: Brain Distribution and Modulation of Neuronal Excitability by Indicaxanthin From Opuntia Ficus Indica Administered at Nutritionally-Relevant Amounts. (2018). https://pubmed.ncbi.nlm.nih.gov/29867444/ DOI: 10.3389/fnagi.2018.00133\nAccess: Primary PubMed abstract; 2018 regional neuronal results additionally inspected in PMC full text.","model_system":"Rats given purified indicaxanthin","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact archived curation span; original paraphrase with primary citation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"18b7303c-98b7-54cb-ae8e-a8c6257657b1","stable_key":"import-c94a9824-35fb-523c-b421-dc7341218dcb","title":"Indicaxanthin: mechanisms, molecular forms and cross-actor connections (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted curation of thirteen additional primary studies, with twenty-six existing claims from eight studies linked unchanged. Study-specific citations and limitations retained. Not publisher full text.","file_path":"","sha256":"fd5e7b3a108073af5a8cad0e226a483ae2cda3b0e1daed387553ee441acecd5f","revision_id":"f3357c22-1be7-5502-b4f5-415d19c3cf5a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}