{"id":"25099c00-b2d1-5b0d-bc1a-f5eb1ce7c076","stable_key":"10629adf-a816-5b7b-82db-a76bfbb946f2:bg-the-cholesterol-claim-was-accepted","predicate":"reduces","statement":"The applicant identified a total of 22 references which included three meta-analyses and 19 randomised controlled trials as being pertinent to the health claim, in weighing the evidence the Panel took into account that most of the trials investigating the effects of oat beta-glucan at doses of at least 3 grams per day have shown a statistically significant decrease in LDL-cholesterol concentrations and that there was strong evidence supporting the biological plausibility of the effect, and the Panel concludes that a cause and effect relationship has been established between the consumption of oat beta-glucan and lowering of blood LDL-cholesterol concentrations, considering that in order to bear the claim foods should provide at least 3 grams of oat beta-glucan per day.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"negative","is_public":true,"mechanism_event_id":"169b8354-a43e-53f6-b9ea-8911753a5e8e","mechanism_event_label":"The cholesterol claim cleared the same regulator, at three grams a day.","subject":{"id":"fa30a72e-ed34-59eb-badd-236561a8db88","slug":"oat-beta-glucan","display_name":"Oat mixed-linkage beta-(1->3)/(1->4)-glucan","entity_type_key":"chemical_species"},"object":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"169b8354-a43e-53f6-b9ea-8911753a5e8e","stable_key":"10629adf-a816-5b7b-82db-a76bfbb946f2:bg-the-cholesterol-claim-was-accepted-event","event_type":"observed_intervention","label":"The cholesterol claim cleared the same regulator, at three grams a day.","description":"The applicant identified a total of 22 references which included three meta-analyses and 19 randomised controlled trials as being pertinent to the health claim, in weighing the evidence the Panel took into account that most of the trials investigating the effects of oat beta-glucan at doses of at least 3 grams per day have shown a statistically significant decrease in LDL-cholesterol concentrations and that there was strong evidence supporting the biological plausibility of the effect, and the Panel concludes that a cause and effect relationship has been established between the consumption of oat beta-glucan and lowering of blood LDL-cholesterol concentrations, considering that in order to bear the claim foods should provide at least 3 grams of oat beta-glucan per day.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"264438cb-3c0e-5ff2-99f3-c486300e5b18","slug":"authorised-health-claim","display_name":"An authorised European health claim and its conditions of use","entity_type_key":"cellular_process"},"role":"regulatory_instrument","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"85090025-4e92-5d9a-8557-80f398f8411e","slug":"coronary-heart-disease","display_name":"Coronary heart disease","entity_type_key":"cellular_process"},"role":"inferred_target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"fa30a72e-ed34-59eb-badd-236561a8db88","slug":"oat-beta-glucan","display_name":"Oat mixed-linkage beta-(1->3)/(1->4)-glucan","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"ac5f5914-4824-5f9b-93c7-a6b5a52b53af","slug":"ldl-cholesterol-concentration","display_name":"LDL cholesterol concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/glucan-research/42004118.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"dcfcf120be06e5235e076afd33caa325371eea0a3c56b74b023ea34589e19717\", \"start_char\": 0, \"end_char\": 1690, \"text_sha256\": \"dcfcf120be06e5235e076afd33caa325371eea0a3c56b74b023ea34589e19717\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"European Food Safety Authority assessment of three meta-analyses and 19 randomised controlled trials","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Oat beta-glucan at doses of at least 3 grams per day","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A regulatory opinion on a disease-risk-reduction claim. 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