{"id":"24db8a53-b3e6-5e72-a3f1-5d310b65dde1","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-zinc-accessibility","predicate":"reduces","statement":"Stronger zinc binding accompanied lower simulated-digestion bioaccessibility.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a5080877-de98-58d9-a832-a99e46e3fa47","mechanism_event_label":"Laboratory accessibility can fall.","subject":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"object":{"id":"334f817e-9983-568d-b336-ff482da8a1da","slug":"in-vitro-zinc-bioaccessibility","display_name":"Zinc bioaccessibility in simulated digestion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a5080877-de98-58d9-a832-a99e46e3fa47","stable_key":"d17caac5-7018-5ca8-9e96-95afeb384bc4:pectin-zinc-accessibility-event","event_type":"biochemical_relationship","label":"Laboratory accessibility can fall.","description":"Stronger zinc binding accompanied lower simulated-digestion bioaccessibility.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"977851e1-fc8d-5138-b332-95264bb1e016","slug":"citrus-pectin","display_name":"Citrus pectin, preparation specified by study","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"334f817e-9983-568d-b336-ff482da8a1da","slug":"in-vitro-zinc-bioaccessibility","display_name":"Zinc bioaccessibility in simulated digestion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/pectin-research/celus2018.publisher-abstract.txt\", \"locator\": \"Primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2ac4b4f67d7dfb4d68a06455691f949be93304d25c3475bd8caf4d618d96f472\", \"start_char\": 0, \"end_char\": 1681, \"text_sha256\": \"2ac4b4f67d7dfb4d68a06455691f949be93304d25c3475bd8caf4d618d96f472\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Adsorption isotherms and simulated digestion","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Citrus pectin with varied methylesterification and blockiness","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"In-vitro accessibility is not human mineral status.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Pectin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"pectin","display_name":"Pectin, structurally heterogeneous plant polysaccharides","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"No organism; in-vitro food chemistry","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Laboratory accessibility can fall.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[pectin-pcelus2018] Interactions between citrus pectin and Zn2+ or Ca2+ and associated in vitro Zn2+ bioaccessibility as affected by degree of methylesterification and blockiness (2018). https://doi.org/10.1016/j.foodhyd.2018.01.003 DOI: 10.1016/j.foodhyd.2018.01.003","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Pectin-mineral solutions","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0c28ce5e-8fbd-5e36-8bec-bb0f48fbd48b","evidence_kind":"source_excerpt","locator":"Lines 516-527","start_line":516,"end_line":527,"excerpt":"### pectin-zinc-accessibility\nStronger zinc binding accompanied lower simulated-digestion bioaccessibility.\nCondition category: normal\nnutrient_topic: Pectin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Laboratory accessibility can fall.\norganism: No organism; in-vitro food chemistry\ntissue_or_cell_type: Pectin-mineral solutions\nexperimental_model: Adsorption isotherms and simulated digestion\nlimitations: In-vitro accessibility is not human mineral status.\nexposure: Citrus pectin with varied methylesterification and blockiness\nevidence_span: {\"source_cache\": \"artifacts/pectin-research/celus2018.publisher-abstract.txt\", \"locator\": \"Primary publisher abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"2ac4b4f67d7dfb4d68a06455691f949be93304d25c3475bd8caf4d618d96f472\", \"start_char\": 0, \"end_char\": 1681, \"text_sha256\": \"2ac4b4f67d7dfb4d68a06455691f949be93304d25c3475bd8caf4d618d96f472\"}\n[pectin-pcelus2018] Interactions between citrus pectin and Zn2+ or Ca2+ and associated in vitro Zn2+ bioaccessibility as affected by degree of methylesterification and blockiness (2018). https://doi.org/10.1016/j.foodhyd.2018.01.003 DOI: 10.1016/j.foodhyd.2018.01.003","model_system":"Adsorption isotherms and simulated digestion","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [pectin-pcelus2018] Interactions between citrus pectin and Zn2+ or Ca2+ and associated in vitro Zn2+ bioaccessibility as affected by degree of methylesterification and blockiness (2018). https://doi.org/10.1016/j.foodhyd.2018.01.003 DOI: 10.1016/j.foodhyd.2018.01.003","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"13c3aae7-702f-5bc9-9fca-a57d141882ce","stable_key":"import-d17caac5-7018-5ca8-9e96-95afeb384bc4","title":"Pectin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"ff07001bc37d008a1e23fbba37146d0b0d33cc8c0bf42a75f1e1a7ef0aaeb489","revision_id":"76f1a2c5-02d0-511b-bde5-33079d7af6a0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}