{"id":"2494ad09-c7df-5ed6-b91d-d2c78bc1880d","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-s-neurosteroids","predicate":"increases","statement":"Erinacine S increased neuronal neurosteroids and promoted neurite outgrowth and post-injury axon regeneration in primary rat neural models.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"40bf1276-dbc4-5bfa-9328-5aa7d1b0003b","mechanism_event_label":"Erinacine S increased neuronal neurosteroids and promoted neurite outgrowth and post-injury axon regeneration in primary rat neural models.","subject":{"id":"150d76c7-72b1-5c50-a332-c6f7e78d32bc","slug":"erinacine-s","display_name":"Erinacine S","entity_type_key":"small_molecule"},"object":{"id":"5a0b87e0-b47c-594e-994a-a0d983f985e7","slug":"neuronal-neurosteroid-accumulation-and-axon-regeneration","display_name":"Neuronal neurosteroid accumulation and axon regeneration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"40bf1276-dbc4-5bfa-9328-5aa7d1b0003b","stable_key":"d39c4b36-9a88-5f52-8e6b-93a248dc4bfc:hericenones-erinacines-erinacine-s-neurosteroids-event","event_type":"observed_relationship","label":"Erinacine S increased neuronal neurosteroids and promoted neurite outgrowth and post-injury axon regeneration in primary rat neural models.","description":"Erinacine S increased neuronal neurosteroids and promoted neurite outgrowth and post-injury axon regeneration in primary rat neural models.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"150d76c7-72b1-5c50-a332-c6f7e78d32bc","slug":"erinacine-s","display_name":"Erinacine S","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"5a0b87e0-b47c-594e-994a-a0d983f985e7","slug":"neuronal-neurosteroid-accumulation-and-axon-regeneration","display_name":"Neuronal neurosteroid accumulation and axon regeneration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"dose","value_text":"Erinacine S with neurosteroidogenesis inhibitors","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"duration","value_text":"Post-injury regeneration assays","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_scope","value_text":"literature_reviewed; model-specific source-derived curation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Primary rat peripheral and central nervous-system neurons","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cell-autonomous rat-neuron effects do not establish recovery after human neurological injury.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Hericenones & Erinacines chapter; interacting nutrients, drugs, peptides and proteins retain their experimental settings.","comparator":null,"unit":null,"notes":"","entity":{"slug":"hericenones-erinacines","display_name":"Hericenones and erinacines","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Primary rat peripheral and central nervous-system neurons","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Erinacine S increased neuronal neurosteroids and promoted neurite outgrowth and post-injury axon regeneration in primary rat neural models.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation. (2023). https://pubmed.ncbi.nlm.nih.gov/37224554/ DOI: 10.38212/2224-6614.3446","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"route","value_text":"In vitro","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue","value_text":"Neurosteroids, neurite outgrowth and axon regeneration","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"dcbefe23-199e-5c6f-a98c-4f8c6bc1e495","evidence_kind":"source_excerpt","locator":"Lines 132-141","start_line":132,"end_line":141,"excerpt":"## hericenones-erinacines-erinacine-s-neurosteroids\nErinacine S increased neuronal neurosteroids and promoted neurite outgrowth and post-injury axon regeneration in primary rat neural models.\nModel/species: Primary rat peripheral and central nervous-system neurons\nTissue/system: Neurosteroids, neurite outgrowth and axon regeneration\nExposure: Erinacine S with neurosteroidogenesis inhibitors\nRoute: In vitro\nDuration: Post-injury regeneration assays\nLimits: Cell-autonomous rat-neuron effects do not establish recovery after human neurological injury.\nPrimary reference: Erinacine S from Hericium erinaceus mycelium promotes neuronal regeneration by inducing neurosteroids accumulation. (2023). https://pubmed.ncbi.nlm.nih.gov/37224554/ DOI: 10.38212/2224-6614.3446\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"Primary rat peripheral and central nervous-system neurons","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact original curation span with primary citation; not a publisher quotation.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"aa7c09fd-ab4a-51ff-b463-d35547dc41ba","stable_key":"import-d39c4b36-9a88-5f52-8e6b-93a248dc4bfc","title":"Hericenones & Erinacines: mechanism of action and interactions (2026-09-20)","document_type":"imported_text","citation_label":"Original AI-assisted source-specific curation with primary-study citations, model, exposure, route, duration, negative findings and limitations preserved. Not publisher full text.","file_path":"","sha256":"f1ff2966f222f5c463e8e509ec1b1642a0053cd38f121f3847cdd21855c46e85","revision_id":"d00076e0-da87-5100-92ed-0525190b25a1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}