{"id":"240da76a-5a66-5c22-8b7f-66ec6efa58b0","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-whole-diet-adjusted-iron-association","predicate":"adjusted_intake_correlates_with_iron_absorption","statement":"Pooled regression adjusted for iron status found a positive association between ascorbic acid intake and absorption (P=0.0069), alongside associations with animal tissue and phosphate.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"277dfd05-757a-5162-a5bf-75d3484cdcae","mechanism_event_label":"The vitamin C association remained visible in an adjusted analysis, even though the period means did not differ significantly.","subject":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"object":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"277dfd05-757a-5162-a5bf-75d3484cdcae","stable_key":"cb568d28-484a-5c2e-9fcc-2d780358e514:c-whole-diet-adjusted-iron-association-event","event_type":"observed_intervention","label":"The vitamin C association remained visible in an adjusted analysis, even though the period means did not differ significantly.","description":"Pooled regression adjusted for iron status found a positive association between ascorbic acid intake and absorption (P=0.0069), alongside associations with animal tissue and phosphate.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"89bcaf42-b4ab-5760-8c2e-44eace10cee0","slug":"iron","display_name":"Iron","entity_type_key":"nutrient_element"},"role":"affected_nutrient","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2047867f-9872-53b2-a553-71c911d0695b","slug":"ascorbic-acid","display_name":"L-Ascorbic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"4429d8ae-d732-5f5e-acc1-2c872e23da62","slug":"nonheme-iron-absorption","display_name":"Nonheme iron absorption","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"cross_nutrient","value_text":"Iron status and dietary matrix affect the observed relationship.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twelve subjects completing three dietary periods; labeled wheat rolls with every meal for five days per period.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Self-selected, low-C and high-C complete diets; mean vitamin C intakes spanned 51–247 mg/day.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Regression within a small dietary experiment is not an isolated randomized causal estimate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Vitamin C research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"vitamin-c","display_name":"Vitamin C","entity_type_key":"chemical_species"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The vitamin C association remained visible in an adjusted analysis, even though the period means did not differ significantly.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[c-cook2001] Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet (2001). https://pubmed.ncbi.nlm.nih.gov/11124756/ DOI: 10.1093/ajcn/73.1.93","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Human blood or whole-person endpoints","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"a92dee71-b1a3-53fa-818d-f6e395b67fc3","evidence_kind":"source_excerpt","locator":"Lines 1606-1617","start_line":1606,"end_line":1617,"excerpt":"### c-whole-diet-adjusted-iron-association\nPooled regression adjusted for iron status found a positive association between ascorbic acid intake and absorption (P=0.0069), alongside associations with animal tissue and phosphate.\nCondition category: normal\nnutrient_topic: Vitamin C research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The vitamin C association remained visible in an adjusted analysis, even though the period means did not differ significantly.\norganism: Homo sapiens\ntissue_or_cell_type: Human blood or whole-person endpoints\nexperimental_model: Twelve subjects completing three dietary periods; labeled wheat rolls with every meal for five days per period.\nlimitations: Regression within a small dietary experiment is not an isolated randomized causal estimate.\nexposure: Self-selected, low-C and high-C complete diets; mean vitamin C intakes spanned 51–247 mg/day.\ncross_nutrient: Iron status and dietary matrix affect the observed relationship.\n[c-cook2001] Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet (2001). https://pubmed.ncbi.nlm.nih.gov/11124756/ DOI: 10.1093/ajcn/73.1.93","model_system":"Twelve subjects completing three dietary periods; labeled wheat rolls with every meal for five days per period.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [c-cook2001] Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet (2001). https://pubmed.ncbi.nlm.nih.gov/11124756/ DOI: 10.1093/ajcn/73.1.93","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"fa811221-13bd-5c10-adc1-eaf097c7703c","stable_key":"import-cb568d28-484a-5c2e-9fcc-2d780358e514","title":"Vitamin C: mechanisms, deficiency and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"b7fd83f956abb81855f2ea23199ba14e465cd91f4a2ac560277ec21ddafd7bfc","revision_id":"6cde9bbb-d712-5746-82a6-85b144253efa","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}