{"id":"23d1407f-61c4-5c61-9543-197fd84391f8","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:sac-animal-pk","predicate":"reported_relationship","statement":"Reported SAC oral bioavailability was 98.2% in rats, 103.0% in mice, and 87.2% in dogs.","claim_class":"observational","status":"source_recorded","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"8736eb79-26c2-568f-9c9f-32d378634a38","mechanism_event_label":"Reported SAC oral bioavailability was 98.2% in rats, 103.0% in mice, and 87.2% in dogs.","subject":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"object":{"id":"bc9ece5f-2908-572c-8fb3-5d52fbe641f6","slug":"animal-sac-oral-bioavailability","display_name":"SAC oral bioavailability in rat mouse and dog pharmacokinetic comparisons","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8736eb79-26c2-568f-9c9f-32d378634a38","stable_key":"c836a883-ac18-5eb2-9971-2f0b542feba8:sac-animal-pk-event","event_type":"experimental_observation","label":"Reported SAC oral bioavailability was 98.2% in rats, 103.0% in mice, and 87.2% in dogs.","description":"**SAC pharmacokinetics are species-specific.** The frequently quoted high oral SAC bioavailability came from rats, mice, and dogs: 98.2%, 103.0%, and 87.2%, respectively, in the cited experiment. An estimate above 100% reflects the pharmacokinetic comparison and experimental variability, not creation of additional dose. These values are not measured human allicin bioavailability. [Nagae 1994](https://pubmed.ncbi.nlm.nih.gov/8073085/)","status":"provisional","compartment":null,"participants":[{"entity":{"id":"8c2c295d-68b3-5e62-b1a7-00fcf915e3cc","slug":"s-allylcysteine","display_name":"S-allyl-L-cysteine / SAC","entity_type_key":"small_molecule"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"bc9ece5f-2908-572c-8fb3-5d52fbe641f6","slug":"animal-sac-oral-bioavailability","display_name":"SAC oral bioavailability in rat mouse and dog pharmacokinetic comparisons","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract reviewed; full methods, exact concentrations or species-specific attribution remain unextracted unless explicitly stated in the abstract or separately verified publisher text.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Species-separated pharmacokinetic estimates; original accessible abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not human values; estimate above 100% is variability, not additional dose. Not allicin pharmacokinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Reported SAC oral bioavailability was 98.2% in rats, 103.0% in mice, and 87.2% in dogs.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Pharmacokinetics of the garlic compound S-allylcysteine. | 1994 | DOI 10.1055/s-2006-959461 | PMID 8073085 | https://pubmed.ncbi.nlm.nih.gov/8073085/ | https://doi.org/10.1055/s-2006-959461","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 35-35; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"761178b4-cbd3-5d21-9b84-7af79b9c6574","evidence_kind":"source_excerpt","locator":"Lines 35-35","start_line":35,"end_line":35,"excerpt":"**SAC pharmacokinetics are species-specific.** The frequently quoted high oral SAC bioavailability came from rats, mice, and dogs: 98.2%, 103.0%, and 87.2%, respectively, in the cited experiment. An estimate above 100% reflects the pharmacokinetic comparison and experimental variability, not creation of additional dose. These values are not measured human allicin bioavailability. [Nagae 1994](https://pubmed.ncbi.nlm.nih.gov/8073085/)","model_system":"Species-separated pharmacokinetic estimates; original accessible abstract.","directness":"reported_statement","verification_status":"source_recorded","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"10820a6b-594a-547d-97f9-906ab4cc1d6e","stable_key":"import-c836a883-ac18-5eb2-9971-2f0b542feba8","title":"Allicin: detailed mechanisms of action (reviewed 5 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"2475d3eb681100a0a34577a47b7cba5b251df866fbd6ce795122ccabee360018","revision_id":"590df96d-2ed1-5763-b04c-bf0e096e603c","review_status":"source_recorded","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}