{"id":"236ca9ab-19ee-5cdc-b337-2289c09d52da","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-pivalate-depletion","predicate":"reduces","statement":"Twelve days of pivmecillinam reduced mean serum free carnitine from 42.8 to 11.6 micromolar, while measured muscle carnitine was unchanged.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"a99e4185-7f7d-51e4-9734-ae0199bdd348","mechanism_event_label":"A drug-associated shortfall can differ between blood and muscle.","subject":{"id":"c0d23d5c-90c3-5d02-8cac-9f7d2bc10d28","slug":"pivmecillinam","display_name":"Pivmecillinam","entity_type_key":"small_molecule"},"object":{"id":"0415581d-4a60-53bd-baf4-17405b3bb41f","slug":"serum-l-carnitine","display_name":"Human serum L-carnitine concentration","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a99e4185-7f7d-51e4-9734-ae0199bdd348","stable_key":"6cdb37aa-8998-5ea8-829d-4f995caf98fc:l-carnitine-pivalate-depletion-event","event_type":"observed_relationship","label":"A drug-associated shortfall can differ between blood and muscle.","description":"Twelve days of pivmecillinam reduced mean serum free carnitine from 42.8 to 11.6 micromolar, while measured muscle carnitine was unchanged.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c0d23d5c-90c3-5d02-8cac-9f7d2bc10d28","slug":"pivmecillinam","display_name":"Pivmecillinam","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"0415581d-4a60-53bd-baf4-17405b3bb41f","slug":"serum-l-carnitine","display_name":"Human serum L-carnitine concentration","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"6e34c035-9371-578f-b799-fd2a14e9e40f","slug":"l-carnitine","display_name":"L-Carnitine","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"06892089-1ad6-5645-80b2-6e949d6489ee","slug":"human-muscle-total-carnitine","display_name":"Human skeletal-muscle total carnitine content","entity_type_key":"cellular_process"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"nutrient_deficiency","comparator":null,"unit":null,"notes":"Imported condition classification; 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