{"id":"2361651c-fbc3-56b0-becc-dd81023e5c0e","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-muscle-release-null","predicate":"did_not_change","statement":"At 20 mM, taurine had no detectable effect on the responsiveness of SR calcium-release channels in either human fiber type.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"a46f9f26-67ea-59e3-b290-a0a0d737149e","mechanism_event_label":"Faster calcium accumulation did not mean every calcium process increased.","subject":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"object":{"id":"179cff4a-37a6-508e-b710-94a9d8ef403d","slug":"human-taurine-calcium-release","display_name":"Human skeletal-muscle SR calcium-release responsiveness","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"a46f9f26-67ea-59e3-b290-a0a0d737149e","stable_key":"1acdb1e8-2159-5c7f-b39f-0153ff8024ae:taurine-muscle-release-null-event","event_type":"observed_relationship","label":"Faster calcium accumulation did not mean every calcium process increased.","description":"At 20 mM, taurine had no detectable effect on the responsiveness of SR calcium-release channels in either human fiber type.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e423cd36-f183-522b-a5e4-5f9ef50eee7e","slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"179cff4a-37a6-508e-b710-94a9d8ef403d","slug":"human-taurine-calcium-release","display_name":"Human skeletal-muscle SR calcium-release responsiveness","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human skinned type I and II muscle fibers.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The proposed action inside the SR lumen was a hypothesis, not a demonstrated binding target.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Taurine collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"taurine","display_name":"Taurine","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Faster calcium accumulation did not mean every calcium process increased.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Acute effects of taurine on sarcoplasmic reticulum Ca2+ accumulation and contractility in human type I and type II skeletal muscle fibers. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25123198/ · DOI 10.1152/japplphysiol.00494.2014","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"492fd8a8-6233-5370-b161-5363c1bc32a9","evidence_kind":"source_excerpt","locator":"Lines 465-471","start_line":465,"end_line":471,"excerpt":"## taurine-muscle-release-null\nFaster calcium accumulation did not mean every calcium process increased.\nAt 20 mM, taurine had no detectable effect on the responsiveness of SR calcium-release channels in either human fiber type.\nModel: Human skinned type I and II muscle fibers.\nLimitations: The proposed action inside the SR lumen was a hypothesis, not a demonstrated binding target.\nEvidence access: Primary abstract\nAcute effects of taurine on sarcoplasmic reticulum Ca2+ accumulation and contractility in human type I and type II skeletal muscle fibers. · 2014 · https://pubmed.ncbi.nlm.nih.gov/25123198/ · DOI 10.1152/japplphysiol.00494.2014","model_system":"Human skinned type I and II muscle fibers.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc8d9ab8-fdf9-5107-877c-336cf8005097","stable_key":"import-1acdb1e8-2159-5c7f-b39f-0153ff8024ae","title":"Taurine: synthesis, transport, mitochondrial decoding and nutrient interactions (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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