{"id":"2337c142-21b0-5a6e-b646-7bcb4ee095a6","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-atp7a-intestinal-response","predicate":"deficiency_increases","statement":"Low systemic copper increased intestinal ATP7A, while subcutaneous copper lowered it in the same mouse study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"63a9a41d-6e8c-50a8-b84b-0e6950d97c4f","mechanism_event_label":"The intestine responded in the opposite direction, consistent with delivering copper to the rest of the body.","subject":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"object":{"id":"54e388b1-0117-590c-8414-4dd2188bee13","slug":"mouse-intestinal-atp7a-abundance","display_name":"Mouse intestinal ATP7A abundance","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"63a9a41d-6e8c-50a8-b84b-0e6950d97c4f","stable_key":"0ad8610d-d575-5870-b7cd-763a9f750783:copper-atp7a-intestinal-response-event","event_type":"biochemical_relationship","label":"The intestine responded in the opposite direction, consistent with delivering copper to the rest of the body.","description":"Low systemic copper increased intestinal ATP7A, while subcutaneous copper lowered it in the same mouse study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4402b6dd-887c-52c1-befa-789a47b8dc38","slug":"mouse-atp7a","display_name":"Mouse copper-transporting ATPase Atp7a","entity_type_key":"protein"},"role":"regulated transporter","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9f0afdde-1ec1-5c8a-bb5e-f3b2b75f67f6","slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"54e388b1-0117-590c-8414-4dd2188bee13","slug":"mouse-intestinal-atp7a-abundance","display_name":"Mouse intestinal ATP7A abundance","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/copper-research/28931909.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"040f84f61342770e57eec0c3e82a0165c000bc5592a54344f92378b48e626c9f\", \"start_char\": 0, \"end_char\": 1284, \"text_sha256\": \"040f84f61342770e57eec0c3e82a0165c000bc5592a54344f92378b48e626c9f\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Copper-deficient mouse models and subcutaneous copper administration","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Systemic copper depletion and restoration","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Opposite tissue responses are reported regulatory context, not a contradiction in the source.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Copper research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"copper","display_name":"Copper","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Mouse","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The intestine responded in the opposite direction, consistent with delivering copper to the rest of the body.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[copper-p28931909] Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis. (2017). https://pubmed.ncbi.nlm.nih.gov/28931909/ DOI: 10.1038/s41598-017-11961-z","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Intestine, heart, spleen and liver","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4bc11c6c-e050-5393-91f0-a1d72706c837","evidence_kind":"source_excerpt","locator":"Lines 507-518","start_line":507,"end_line":518,"excerpt":"### copper-atp7a-intestinal-response\nLow systemic copper increased intestinal ATP7A, while subcutaneous copper lowered it in the same mouse study.\nCondition category: normal\nnutrient_topic: Copper research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The intestine responded in the opposite direction, consistent with delivering copper to the rest of the body.\norganism: Mouse\ntissue_or_cell_type: Intestine, heart, spleen and liver\nexperimental_model: Copper-deficient mouse models and subcutaneous copper administration\nlimitations: Opposite tissue responses are reported regulatory context, not a contradiction in the source.\nexposure: Systemic copper depletion and restoration\nevidence_span: {\"source_cache\": \"artifacts/copper-research/28931909.abstract.txt\", \"locator\": \"Exact primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"040f84f61342770e57eec0c3e82a0165c000bc5592a54344f92378b48e626c9f\", \"start_char\": 0, \"end_char\": 1284, \"text_sha256\": \"040f84f61342770e57eec0c3e82a0165c000bc5592a54344f92378b48e626c9f\"}\n[copper-p28931909] Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis. (2017). https://pubmed.ncbi.nlm.nih.gov/28931909/ DOI: 10.1038/s41598-017-11961-z","model_system":"Copper-deficient mouse models and subcutaneous copper administration","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [copper-p28931909] Organ-specific regulation of ATP7A abundance is coordinated with systemic copper homeostasis. (2017). https://pubmed.ncbi.nlm.nih.gov/28931909/ DOI: 10.1038/s41598-017-11961-z","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"9afba495-cbdc-51aa-998e-70a930dba3be","stable_key":"import-0ad8610d-d575-5870-b7cd-763a9f750783","title":"Copper: transport, cuproenzymes, deficiency, excess and nutrient interactions (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"84b0f62b2dae6835fa26902be87625c003c6c707492d3007e8f9d15420669008","revision_id":"d7e35b8b-3f77-56d9-90b5-5f542c63f321","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}