{"id":"23014cd7-df6d-5c7c-8651-5120cd450a7d","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-eczema","predicate":"improves_trial_global_score","statement":"Investigator global response favored topical CHD-FA over vehicle; several other measures improved in both groups.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e858351f-d4cf-5f9d-b435-e6c1821623d0","mechanism_event_label":"One overall score favored the active topical preparation.","subject":{"id":"5184fd06-5a8e-5e9d-99ec-c2feaa59ccde","slug":"carbohydrate-derived-fulvic-acid","display_name":"Carbohydrate-derived fulvic acid / CHD-FA (preparation class)","entity_type_key":"chemical_species"},"object":{"id":"b67116bf-c8fc-5ecd-aed9-67e81a919665","slug":"human-chdfa-eczema-score","display_name":"Investigator global eczema response in topical CHD-FA trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"e858351f-d4cf-5f9d-b435-e6c1821623d0","stable_key":"788beb7b-7928-5f89-83d4-5556abf3702c:fulvic-acid-eczema-event","event_type":"observed_relationship","label":"One overall score favored the active topical preparation.","description":"Investigator global response favored topical CHD-FA over vehicle; several other measures improved in both groups.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"5184fd06-5a8e-5e9d-99ec-c2feaa59ccde","slug":"carbohydrate-derived-fulvic-acid","display_name":"Carbohydrate-derived fulvic acid / CHD-FA (preparation class)","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b67116bf-c8fc-5ecd-aed9-67e81a919665","slug":"human-chdfa-eczema-score","display_name":"Investigator global eczema response in topical CHD-FA trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"0aa6c0fc-8374-56e0-b172-6c40b6366d21","slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"36 volunteers aged at least two years; twice-daily topical treatment for four weeks; randomized blinded study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small exploratory trial; do not convert within-group improvement into a between-group benefit. Transient burning occurred; topical results do not prove oral efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Fulvic acid collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"fulvic-acid","display_name":"Fulvic acid (heterogeneous humic fraction)","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"One overall score favored the active topical preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Randomized, parallel-group, double-blind, controlled study to evaluate the efficacy and safety of carbohydrate-derived fulvic acid in topical treatment of eczema. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21931500/ · DOI 10.2147/CCID.S23110","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3528b274-1eb8-5a49-b03c-e25be68aeed8","evidence_kind":"source_excerpt","locator":"Lines 276-282","start_line":276,"end_line":282,"excerpt":"## fulvic-acid-eczema\nOne overall score favored the active topical preparation.\nInvestigator global response favored topical CHD-FA over vehicle; several other measures improved in both groups.\nModel: 36 volunteers aged at least two years; twice-daily topical treatment for four weeks; randomized blinded study.\nLimitations: Small exploratory trial; do not convert within-group improvement into a between-group benefit. Transient burning occurred; topical results do not prove oral efficacy.\nEvidence access: Primary abstract\nRandomized, parallel-group, double-blind, controlled study to evaluate the efficacy and safety of carbohydrate-derived fulvic acid in topical treatment of eczema. · 2011 · https://pubmed.ncbi.nlm.nih.gov/21931500/ · DOI 10.2147/CCID.S23110","model_system":"36 volunteers aged at least two years; twice-daily topical treatment for four weeks; randomized blinded study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b00a1818-46e4-52cc-8dfe-a647d5c08ed7","stable_key":"import-788beb7b-7928-5f89-83d4-5556abf3702c","title":"Fulvic acid: mixture identity, mineral chemistry, signaling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"52c2c3ee6bb23d943a40e1c39dd9de5cca7acd6efa72479cb824149e85cc7968","revision_id":"94dfc01b-c93e-55ff-8f48-bb2e9a1979f6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}