{"id":"22fff0c5-ab7d-541a-aaa2-e7e648d7e9cb","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-raises-nrf2","predicate":"increases","statement":"(+)-Lariciresinol increased Nrf2 at both transcriptional and translational levels.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"0e5876d3-4568-5173-9b15-5470d1a9f13f","mechanism_event_label":"(+)-Lariciresinol increased Nrf2 at both transcriptional and translational levels.","subject":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"object":{"id":"dc472dd3-d383-567a-ab37-a9ec4e112df4","slug":"nfe2l2","display_name":"Human Nrf2 / NFE2L2","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"0e5876d3-4568-5173-9b15-5470d1a9f13f","stable_key":"96d9034a-2550-5f3c-b767-1767c982533c:plus-lariciresinol-raises-nrf2-event","event_type":"observed_relationship","label":"(+)-Lariciresinol increased Nrf2 at both transcriptional and translational levels.","description":"(+)-Lariciresinol increased Nrf2 at both transcriptional and translational levels.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"09e8fc4d-e8f7-569b-a427-4c271f523a30","slug":"plus-lariciresinol","display_name":"(+)-Lariciresinol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"dc472dd3-d383-567a-ab37-a9ec4e112df4","slug":"nfe2l2","display_name":"Human Nrf2 / NFE2L2","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e62ed16-0010-5b56-acf2-f0684433098d","slug":"p38-mapk","display_name":"p38 mitogen-activated protein kinase family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"duration","value_text":"Not stated here","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"evidence_access","value_text":"Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"(+)-Lariciresinol, dose-dependent, without cytotoxicity","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Measured as transcript and protein level rather than as nuclear translocation in the abstract.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"organism","value_text":"RAW 264.7 murine macrophages","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"(+)-Lariciresinol increased Nrf2 at both transcriptional and translational levels.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antioxidant efficacy and the upregulation of Nrf2-mediated HO-1 expression by (+)-lariciresinol, a lignan isolated from Rubia philippinensis, through the activation of p38. 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(2017). https://pubmed.ncbi.nlm.nih.gov/28378774/ DOI: 10.1038/srep46035\nAccess: Primary PubMed abstract and indexed metadata reviewed. Full-text method details not stated here remain unresolved.","model_system":"","directness":"reported_statement","verification_status":"source_derived_draft","notes":"","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"48c58761-0291-5bad-a926-75e904b2d802","stable_key":"import-96d9034a-2550-5f3c-b767-1767c982533c","title":"Lariciresinol: five molecules under one name, and the mechanisms each one carries (2026-09-22)","document_type":"imported_text","citation_label":"Original AI-assisted curation of twelve primary studies, every abstract read and all DOIs cross-checked against live PubMed metadata. Mechanism edges only, with no conclusion or claim of benefit recorded. Three author clusters account for eight of the twelve and carry shared laboratory keys. Study-specific concentrations, negative findings and limitations retained. 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