{"id":"22db3a9a-7daf-5fd1-bc0a-89009dfe4973","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-umami-receptor","predicate":"activates","statement":"Coexpressed human T1R1/T1R3 responded to L-glutamate in receptor assays.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4064f23d-133c-579d-b537-4aa44f94f451","mechanism_event_label":"Two receptor proteins recognize the umami signal.","subject":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"object":{"id":"1d944380-d3e6-5e01-9649-43407fbcf8ed","slug":"human-tas1r1-tas1r3","display_name":"Human umami receptor TAS1R1/TAS1R3","entity_type_key":"protein_complex"},"evidence_count":1,"mechanism_event":{"id":"4064f23d-133c-579d-b537-4aa44f94f451","stable_key":"b7014def-74ec-599e-8347-167e24fec1f0:glutamate-umami-receptor-event","event_type":"observed_relationship","label":"Two receptor proteins recognize the umami signal.","description":"Coexpressed human T1R1/T1R3 responded to L-glutamate in receptor assays.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"7da684a4-2641-5bc6-93ae-8c6aa384e487","slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"1d944380-d3e6-5e01-9649-43407fbcf8ed","slug":"human-tas1r1-tas1r3","display_name":"Human umami receptor TAS1R1/TAS1R3","entity_type_key":"protein_complex"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2c1c5c5f-2f58-545e-9a08-b2a63ba1c8f5","slug":"tas1r1","display_name":"Human taste receptor TAS1R1","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"7ab6f209-2089-5008-b64e-64f8db8c7771","slug":"tas1r3","display_name":"Human taste receptor TAS1R3","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Heterologous expression of human taste receptors.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Taste-receptor activation does not establish a brain neurotransmitter effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"L-Glutamate collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"glutamate","display_name":"L-Glutamate","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Two receptor proteins recognize the umami signal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Human receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e6dfd4b1-9069-5b44-a06b-9b2ec5596b13","evidence_kind":"source_excerpt","locator":"Lines 42-48","start_line":42,"end_line":48,"excerpt":"## glutamate-umami-receptor\nTwo receptor proteins recognize the umami signal.\nCoexpressed human T1R1/T1R3 responded to L-glutamate in receptor assays.\nModel: Heterologous expression of human taste receptors.\nLimitations: Taste-receptor activation does not establish a brain neurotransmitter effect.\nEvidence access: Primary abstract\nHuman receptors for sweet and umami taste. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11917125/ · DOI 10.1073/pnas.072090199","model_system":"Heterologous expression of human taste receptors.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"c6a55239-e808-5ed7-9fa3-755a18ecb29f","stable_key":"import-b7014def-74ec-599e-8347-167e24fec1f0","title":"L-Glutamate / L-glutamic acid: carbon and nitrogen allocation, signaling and cross-nutrient mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"3da83bd75fddeb96d17af72d7e2ae04344779957650f266521f6c8ebd59fb54f","revision_id":"55196c72-94e4-540a-a869-81d35647b04a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}