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It is recombinant receptor electrophysiology.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Alcohol research collection; topical membership is not evidence of a direct clinical effect, and ethanol is recorded separately from the acetaldehyde it becomes.","comparator":null,"unit":null,"notes":"","entity":{"slug":"ethanol","display_name":"Ethanol","entity_type_key":"drug"}},{"dimension":"organism","value_text":"Recombinant receptor","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Make the pocket smaller and alcohol works less, which is what a real binding site looks like.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[alcohol-p9452448] Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267. 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It is recombinant receptor electrophysiology.\nexposure: A series of alcohols against residue volume at alpha267\nevidence_span: {\"source_cache\": \"artifacts/alcohol-research/9452448.abstract.txt\", \"locator\": \"Indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e1dd90423748e82a02cec583a8bbfcfd2ee9dcf8da9c126ddf5c5198011820ec\", \"start_char\": 0, \"end_char\": 1618, \"text_sha256\": \"e1dd90423748e82a02cec583a8bbfcfd2ee9dcf8da9c126ddf5c5198011820ec\"}\n[alcohol-p9452448] Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267. (1998). https://pubmed.ncbi.nlm.nih.gov/9452448/ DOI: 10.1074/jbc.273.6.3314","model_system":"Site-directed mutagenesis of glycine receptor position alpha267 with alcohols of differing size","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [alcohol-p9452448] Enhancement of glycine receptor function by ethanol is inversely correlated with molecular volume at position alpha267. (1998). https://pubmed.ncbi.nlm.nih.gov/9452448/ DOI: 10.1074/jbc.273.6.3314","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"4b310db0-1387-548c-9e3d-6d2ed634b2cd","stable_key":"import-fcc4fa9c-4dc8-5566-b780-1a486c4d3e72","title":"Alcohol: ethanol clearance, acetaldehyde, the channels it binds, organ injury and nutrient collisions (2026-09-21)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"cb7e8dc390e8bf302cd5e230cadff6ce9847b4aad8a3691a308964d93ba59a85","revision_id":"4b344e1e-4129-579c-a058-50262b03f9a8","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}