{"id":"228b5a07-45c8-5470-bfb7-23f5594c20a8","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-microbial-count","predicate":"decreases","statement":"Norathyriol reduced overall bacterial cell counts in the tested cultures.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"77733ec9-8f06-50e7-b1a2-b66c4e9d18d5","mechanism_event_label":"Its metabolite changed bacterial growth.","subject":{"id":"d0f7f42a-ac45-5144-9ea5-a7586896cc6e","slug":"norathyriol","display_name":"Norathyriol","entity_type_key":"small_molecule"},"object":{"id":"9c041e95-6560-5ac2-a6fc-e6d519b1842a","slug":"human-fecal-bacterial-abundance","display_name":"Bacterial cell abundance in human fecal cultures","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"77733ec9-8f06-50e7-b1a2-b66c4e9d18d5","stable_key":"475ea55a-65e9-51c3-a539-738a6a8f683f:mangiferin-microbial-count-event","event_type":"biochemical_relationship","label":"Its metabolite changed bacterial growth.","description":"Norathyriol reduced overall bacterial cell counts in the tested cultures.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d0f7f42a-ac45-5144-9ea5-a7586896cc6e","slug":"norathyriol","display_name":"Norathyriol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9c041e95-6560-5ac2-a6fc-e6d519b1842a","slug":"human-fecal-bacterial-abundance","display_name":"Bacterial cell abundance in human fecal cultures","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/mangiferin-research/40401774.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\", \"start_char\": 0, \"end_char\": 1390, \"text_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Ex vivo human fecal fermentation and metagenomic profiling","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Mangiferin or norathyriol 500 micromolar in culture; not participant supplementation","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Community findings do not establish health benefit or harm in people; candidate converter taxa were associations, not isolated causal proof.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Mangiferin research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"mangiferin","display_name":"Mangiferin","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human-derived microbial communities","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Its metabolite changed bacterial growth.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[mangiferin-p40401774] Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism. (2025). https://pubmed.ncbi.nlm.nih.gov/40401774/ DOI: 10.1080/19490976.2025.2508422","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Fecal cultures","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4e66b7eb-8288-5756-8cc3-c01e64a588ac","evidence_kind":"source_excerpt","locator":"Lines 158-169","start_line":158,"end_line":169,"excerpt":"### mangiferin-microbial-count\nNorathyriol reduced overall bacterial cell counts in the tested cultures.\nCondition category: normal\nnutrient_topic: Mangiferin research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: Its metabolite changed bacterial growth.\norganism: Human-derived microbial communities\ntissue_or_cell_type: Fecal cultures\nexperimental_model: Ex vivo human fecal fermentation and metagenomic profiling\nlimitations: Community findings do not establish health benefit or harm in people; candidate converter taxa were associations, not isolated causal proof.\nexposure: Mangiferin or norathyriol 500 micromolar in culture; not participant supplementation\nevidence_span: {\"source_cache\": \"artifacts/mangiferin-research/40401774.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\", \"start_char\": 0, \"end_char\": 1390, \"text_sha256\": \"56539abd79e79a7968a5ec040d9fff33a864b228236cfecba1c7e0ccd3eae380\"}\n[mangiferin-p40401774] Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism. (2025). https://pubmed.ncbi.nlm.nih.gov/40401774/ DOI: 10.1080/19490976.2025.2508422","model_system":"Ex vivo human fecal fermentation and metagenomic profiling","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [mangiferin-p40401774] Gut microbiota-mediated conversion of mangiferin to norathyriol alters short chain fatty acid and urate metabolism. (2025). https://pubmed.ncbi.nlm.nih.gov/40401774/ DOI: 10.1080/19490976.2025.2508422","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"267f942a-695a-5b62-a858-f71c06321ff5","stable_key":"import-475ea55a-65e9-51c3-a539-738a6a8f683f","title":"Mangiferin: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"295cb3a13742b3caeed19347ffcbc7863f5372d983da1625a942428919b4dc98","revision_id":"d9c2ee89-ff22-5e86-9d7f-7cb7e17f9ed2","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}